DNA methylation-based predictors of health: applications and statistical considerations
DNA methylation data have become a valuable source of information for biomarker
development, because, unlike static genetic risk estimates, DNA methylation varies …
development, because, unlike static genetic risk estimates, DNA methylation varies …
Epigenetic clock: A promising biomarker and practical tool in aging
R Duan, Q Fu, Y Sun, Q Li - Ageing Research Reviews, 2022 - Elsevier
As a complicated process, aging is characterized by various changes at the cellular,
subcellular and nuclear levels, one of which is epigenetic aging. With increasing awareness …
subcellular and nuclear levels, one of which is epigenetic aging. With increasing awareness …
Genetic variation influencing DNA methylation provides insights into molecular mechanisms regulating genomic function
We determined the relationships between DNA sequence variation and DNA methylation
using blood samples from 3,799 Europeans and 3,195 South Asians. We identify …
using blood samples from 3,799 Europeans and 3,195 South Asians. We identify …
[HTML][HTML] Ageing–oxidative stress, PTMs and disease
Post-translational modifications (PTMs) have been proposed as a link between the oxidative
stress-inflammation-ageing trinity, thereby affecting several hallmarks of ageing …
stress-inflammation-ageing trinity, thereby affecting several hallmarks of ageing …
In utero exposure to the Great Depression is reflected in late-life epigenetic aging signatures
LL Schmitz, V Duque - … of the National Academy of Sciences, 2022 - National Acad Sciences
Research on maternal-fetal epigenetic programming argues that adverse exposures to the
intrauterine environment can have long-term effects on adult morbidity and mortality …
intrauterine environment can have long-term effects on adult morbidity and mortality …
Epigenetic aging: Biological age prediction and informing a mechanistic theory of aging
Numerous studies have shown that epigenetic age—an individual's degree of aging based
on patterns of DNA methylation—can be computed and is associated with an array of factors …
on patterns of DNA methylation—can be computed and is associated with an array of factors …
Frailty biomarkers under the perspective of geroscience: a narrative review
RSSA Gonçalves, ÁCC Maciel, Y Rolland… - Ageing research …, 2022 - Elsevier
Cellular and molecular aging biomarkers might contribute to identify at-risk individuals for
frailty before overt clinical manifestations appear. Although studies on the associations of …
frailty before overt clinical manifestations appear. Although studies on the associations of …
A single short reprogramming early in life initiates and propagates an epigenetically related mechanism improving fitness and promoting an increased healthy lifespan
Q Alle, E Le Borgne, P Bensadoun, C Lemey… - Aging …, 2022 - Wiley Online Library
Recent advances in cell reprogramming showed that OSKM induction is able to improve cell
physiology in vitro and in vivo. Here, we show that a single short reprogramming induction is …
physiology in vitro and in vivo. Here, we show that a single short reprogramming induction is …
Overview of polyamines as nutrients for human healthy long life and effect of increased polyamine intake on DNA methylation
K Soda - Cells, 2022 - mdpi.com
Polyamines, spermidine and spermine, are synthesized in every living cell and are therefore
contained in foods, especially in those that are thought to contribute to health and longevity …
contained in foods, especially in those that are thought to contribute to health and longevity …
How to slow down the ticking clock: age-associated epigenetic alterations and related interventions to extend life span
Epigenetic alterations pose one major hallmark of organismal aging. Here, we provide an
overview on recent findings describing the epigenetic changes that arise during aging and …
overview on recent findings describing the epigenetic changes that arise during aging and …