Cell death pathways have evolved to maintain tissue homoeostasis and eliminate potentially
harmful cells from within an organism, such as cells with damaged DNA that could lead to …

As an important form of posttranslational modification, protein ubiquitination regulates a
wide variety of biological processes, including different aspects of T cell development and …

Homeostasis is achieved by balancing cell survival and death. In cancer cells, especially
those carrying driver mutations, the processes and signals that promote apoptosis are …

RANKL induces NFATc1, a key transcriptional factor to induce osteoclast-specific genes
such as cathepsin K, whereas transcriptional control of osteoclast survival is not fully …

Osteoporosis (OP) is a major and growing public health problem characterized by
decreased bone mineral density and destroyed bone microarchitecture. Previous studies …