Mitochondrial and metabolic dysfunction in ageing and age-related diseases
Organismal ageing is accompanied by progressive loss of cellular function and systemic
deterioration of multiple tissues, leading to impaired function and increased vulnerability to …
deterioration of multiple tissues, leading to impaired function and increased vulnerability to …
[HTML][HTML] Extrachromosomal circular DNA in cancer: history, current knowledge, and methods
Extrachromosomal circular DNA (eccDNA) is a closed-circle, nuclear, nonplasmid DNA
molecule found in all tested eukaryotes. eccDNA plays important roles in cancer …
molecule found in all tested eukaryotes. eccDNA plays important roles in cancer …
rDNA array length is a major determinant of replicative lifespan in budding yeast
The complex processes and interactions that regulate aging and determine lifespan are not
fully defined for any organism. Here, taking advantage of recent technological advances in …
fully defined for any organism. Here, taking advantage of recent technological advances in …
[HTML][HTML] Extrachromosomal circular DNA: a neglected nucleic acid molecule in plants
Throughout the years, most plant genomic studies were focused on nuclear chromosomes.
Extrachromosomal circular DNA (eccDNA) has largely been neglected for decades since its …
Extrachromosomal circular DNA (eccDNA) has largely been neglected for decades since its …
eccDNAdb: a database of extrachromosomal circular DNA profiles in human cancers
L Peng, N Zhou, CY Zhang, GC Li, XQ Yuan - Oncogene, 2022 - nature.com
E xtra c hromosomal c ircular DNA (eccDNA) elements are circular DNA molecules that are
derived from but are independent of chromosomal DNA. EccDNA is emerging as a rising …
derived from but are independent of chromosomal DNA. EccDNA is emerging as a rising …
Extrachromosomal circular DNA: biogenesis, structure, functions and diseases
L Yang, R Jia, T Ge, S Ge, A Zhuang, P Chai… - Signal Transduction and …, 2022 - nature.com
Extrachromosomal circular DNA (eccDNA), ranging in size from tens to millions of base
pairs, is independent of conventional chromosomes. Recently, eccDNAs have been …
pairs, is independent of conventional chromosomes. Recently, eccDNAs have been …
Age-dependent aggregation of ribosomal RNA-binding proteins links deterioration in chromatin stability with challenges to proteostasis
Chromatin instability and protein homeostasis (proteostasis) stress are two wellestablished
hallmarks of aging, which have been considered largely independent of each other. Using …
hallmarks of aging, which have been considered largely independent of each other. Using …
[HTML][HTML] A unifying model for extrachromosomal circular DNA load in eukaryotic cells
Extrachromosomal circular DNA (eccDNA) with exons and whole genes are common
features of eukaryotic cells. Work from especially tumours and the yeast Saccharomyces …
features of eukaryotic cells. Work from especially tumours and the yeast Saccharomyces …
ECCsplorer: a pipeline to detect extrachromosomal circular DNA (eccDNA) from next-generation sequencing data
Abstract Background Extrachromosomal circular DNAs (eccDNAs) are ring-like DNA
structures physically separated from the chromosomes with 100 bp to several …
structures physically separated from the chromosomes with 100 bp to several …
The flavonoid corylin exhibits lifespan extension properties in mouse
TH Wang, WC Tseng, YL Leu, CY Chen… - Nature …, 2022 - nature.com
In the long history of traditional Chinese medicine, single herbs and complex formulas have
been suggested to increase lifespan. However, the identification of single molecules …
been suggested to increase lifespan. However, the identification of single molecules …