Glycosylation in SARS-CoV-2 variants: A path to infection and recovery

A Aloor, R Aradhya, P Venugopal, BG Nair… - Biochemical …, 2022 - Elsevier
Glycan is an essential molecule that controls and drives life in a precise direction. The
paucity of research in glycobiology may impede the significance of its role in the pandemic …

[HTML][HTML] Inhibitory immune checkpoint receptors and ligands as prognostic biomarkers in COVID-19 patients

MA Al-Mterin, A Alsalman, E Elkord - Frontiers in immunology, 2022 - frontiersin.org
Coronavirus disease 2019 (COVID-19) is caused by SARS-CoV-2. During T-cell activation,
the immune system uses different checkpoint pathways to maintain co-inhibitory and co …

[HTML][HTML] Galectin-9 supports primary T cell transendothelial migration in a glycan and integrin dependent manner

AA Mansour, F Raucci, M Sevim, A Saviano… - Biomedicine & …, 2022 - Elsevier
Adaptive immunity relies on the efficient recruitment of T cells from the blood into peripheral
tissues. However, the current understanding of factor (s) coordinating these events is …

[HTML][HTML] Hematopoietic responses to SARS-CoV-2 infection

S Elahi - Cellular and Molecular Life Sciences, 2022 - Springer
Under physiological conditions, hematopoietic stem and progenitor cells (HSPCs) in the
bone marrow niches are responsible for the highly regulated and interconnected …

[HTML][HTML] Integrated plasma proteomic and single-cell immune signaling network signatures demarcate mild, moderate, and severe COVID-19

D Feyaerts, J Hedou, J Gillard, H Chen, ES Tsai… - Cell Reports …, 2022 - cell.com
The biological determinants underlying the range of coronavirus 2019 (COVID-19) clinical
manifestations are not fully understood. Here, over 1,400 plasma proteins and 2,600 single …

[HTML][HTML] Short-chain fatty acids impair neutrophil antiviral function in an age-dependent manner

FJ Carrillo-Salinas, S Parthasarathy, L Moreno de Lara… - Cells, 2022 - mdpi.com
Half of the people living with HIV are women. Younger women remain disproportionally
affected in endemic areas, but infection rates in older women are rising worldwide. The …

Galectin-8, cytokines, and the storm

Y Zick - Biochemical Society Transactions, 2022 - portlandpress.com
Galectin-8 (Gal-8) belongs to a family of animal lectins that modulate cell adhesion, cell
proliferation, apoptosis, and immune responses. Recent studies have shown that …

[HTML][HTML] Galectin‐9 activates platelet ITAM receptors glycoprotein VI and C‐type lectin‐like receptor‐2

Z Zhi, NJ Jooss, Y Sun, M Colicchia, A Slater… - Journal of Thrombosis …, 2022 - Elsevier
Background Platelets are multifunctional cellular mediators in many physiological and
pathophysiological processes such as thrombosis, angiogenesis, and inflammation. Several …

[HTML][HTML] Human milk oligosaccharide 2′-fucosyllactose modulates local viral immune defense by supporting the regulatory functions of intestinal epithelial and …

V Ayechu-Muruzabal, B Poelmann, AJ Berends… - International Journal of …, 2022 - mdpi.com
Human milk contains bioactive components that provide protection against viral infections in
early life. In particular, intestinal epithelial cells (IEC) have key regulatory roles in the …

[HTML][HTML] Cellular and molecular mechanism of pulmonary fibrosis post-COVID-19: Focus on galectin-1,-3,-8,-9

D Oatis, E Simon-Repolski, C Balta, A Mihu… - International Journal of …, 2022 - mdpi.com
Pulmonary fibrosis is a consequence of the pathological accumulation of extracellular matrix
(ECM), which finally leads to lung scarring. Although the pulmonary fibrogenesis is almost …