Donor selection based on NK alloreactivity for patients with hematological malignancies

QJ Zhang - Human Immunology, 2022 - Elsevier
Natural killer (NK) cells are an important defender against infections and tumors. Their
function is regulated by the balance of inhibitory and activating receptors. Among all …

[HTML][HTML] Natural killer cells in antibody independent and antibody dependent HIV control

NF Bernard, S Kant, Z Kiani, C Tremblay… - Frontiers in …, 2022 - frontiersin.org
Infection with the human immunodeficiency virus (HIV), when left untreated, typically leads to
disease progression towards acquired immunodeficiency syndrome. Some people living …

[HTML][HTML] Immunogenomics of killer cell immunoglobulin-like receptor (KIR) and HLA class I: coevolution and consequences for human health

NR Pollock, GF Harrison, PJ Norman - The Journal of Allergy and Clinical …, 2022 - Elsevier
Interactions of killer cell immunoglobin-like receptors (KIR) with human leukocyte antigens
(HLA) class I regulate effector functions of key cytotoxic cells of innate and adaptive …

[HTML][HTML] Individualized constellation of killer cell immunoglobulin-like receptors and cognate HLA class I ligands that controls natural killer cell antiviral immunity …

S Maruthamuthu, K Rajalingam, N Kaur… - Frontiers in …, 2022 - frontiersin.org
Background: The severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) infection
causes coronavirus disease-2019 (COVID-19) in some individuals, while the majority …

[HTML][HTML] Contribution of HLA and KIR alleles to systemic sclerosis susceptibility and immunological and clinical disease subtypes

AL Hanson, J Sahhar, GS Ngian, J Roddy… - Frontiers in …, 2022 - frontiersin.org
Systemic sclerosis (SSc) is an autoinflammatory, fibrotic condition of unknown aetiology. The
presence of detectable autoantibodies against diverse nuclear antigens, as well as strong …

[HTML][HTML] Allele imputation for the killer cell immunoglobulin-like receptor KIR3DL1/S1

GF Harrison, LA Leaton, EA Harrison… - PLoS Computational …, 2022 - journals.plos.org
Highly polymorphic interaction of KIR3DL1 and KIR3DS1 with HLA class I ligands
modulates the effector functions of natural killer (NK) cells and some T cells. This genetically …

Protective HLA-B57: T cell and natural killer cell recognition in HIV infection

CA Lobos, J Downing, LJ D'Orsogna… - Biochemical Society …, 2022 - portlandpress.com
Understanding the basis of the immune determinants controlling disease outcome is critical
to provide better care to patients and could be exploited for therapeutics and vaccine design …

[HTML][HTML] NK Cells in Protection from HIV Infection

NF Bernard, K Alsulami, E Pavey, FP Dupuy - Viruses, 2022 - mdpi.com
Some people, known as HIV-exposed seronegative (HESN) individuals, remain uninfected
despite high levels of exposure to HIV. Understanding the mechanisms underlying their …

[PDF][PDF] Epitope length variants balance protective immune responses and viral escape in HIV-1 infection

P Pymm, S Tenzer, E Wee, M Weimershaus… - Cell reports, 2022 - cell.com
Cytotoxic T lymphocyte (CTL) and natural killer (NK) cell responses to a single optimal 10-
mer epitope (KK10) in the human immunodeficiency virus type-1 (HIV-1) protein p24Gag are …

[PDF][PDF] Contribution des cellules tueuses naturelles chez les sujets contrôleurs d'élite du VIH

S Kant, FP Dupuy, Z Kiani, CL Tremblay… - Virologie (Montrouge …, 2022 - pnmvh.org
En l'absence de traitement antirétroviral, l'infection par le VIH progresse normalement vers
le syndrome d'immunodéficience acquise. Une minorité de sujets infectés par le VIH sont …