Infection with the human immunodeficiency virus (HIV), when left untreated, typically leads to disease progression towards acquired immunodeficiency syndrome. Some people living …
NR Pollock, GF Harrison, PJ Norman - The Journal of Allergy and Clinical …, 2022 - Elsevier
Interactions of killer cell immunoglobin-like receptors (KIR) with human leukocyte antigens (HLA) class I regulate effector functions of key cytotoxic cells of innate and adaptive …
Background: The severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) infection causes coronavirus disease-2019 (COVID-19) in some individuals, while the majority …
AL Hanson, J Sahhar, GS Ngian, J Roddy… - Frontiers in …, 2022 - frontiersin.org
Systemic sclerosis (SSc) is an autoinflammatory, fibrotic condition of unknown aetiology. The presence of detectable autoantibodies against diverse nuclear antigens, as well as strong …
GF Harrison, LA Leaton, EA Harrison… - PLoS Computational …, 2022 - journals.plos.org
Highly polymorphic interaction of KIR3DL1 and KIR3DS1 with HLA class I ligands modulates the effector functions of natural killer (NK) cells and some T cells. This genetically …
CA Lobos, J Downing, LJ D'Orsogna… - Biochemical Society …, 2022 - portlandpress.com
Understanding the basis of the immune determinants controlling disease outcome is critical to provide better care to patients and could be exploited for therapeutics and vaccine design …
NF Bernard, K Alsulami, E Pavey, FP Dupuy - Viruses, 2022 - mdpi.com
Some people, known as HIV-exposed seronegative (HESN) individuals, remain uninfected despite high levels of exposure to HIV. Understanding the mechanisms underlying their …
P Pymm, S Tenzer, E Wee, M Weimershaus… - Cell reports, 2022 - cell.com
Cytotoxic T lymphocyte (CTL) and natural killer (NK) cell responses to a single optimal 10- mer epitope (KK10) in the human immunodeficiency virus type-1 (HIV-1) protein p24Gag are …
S Kant, FP Dupuy, Z Kiani, CL Tremblay… - Virologie (Montrouge …, 2022 - pnmvh.org
En l'absence de traitement antirétroviral, l'infection par le VIH progresse normalement vers le syndrome d'immunodéficience acquise. Une minorité de sujets infectés par le VIH sont …