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A major limitation of organ allotransplantation is the insufficient supply of donor organs.
Consequently, thousands of patients die every year while waiting for a transplant. Progress …

A radical solution is needed for the organ supply crisis, and the domestic pig is a promising
organ source. In preparation for a clinical trial of xenotransplantation, we developed an in …

Pig epiblast-derived pluripotent stem cells are considered to have great potential and broad
prospects for human therapeutic model development and livestock breeding. Despite …

Porcine cells devoid of three major carbohydrate xenoantigens, αGal, Neu5GC, and SDa
(TKO) exhibit markedly reduced binding of human natural antibodies. Therefore, it is …

Animal models of human diseases play a critical role in medical research. Pigs are
anatomically and physiologically more like humans than are small rodents such as mice …

The practice of xenotransplantation using pig islet cells or organs is under development to
alleviate the shortage of human donor islet cells or organs for the treatment of diabetes or …

Transplantation is often the last resort for end-stage organ failures, eg, kidney, liver, heart,
lung, and pancreas. The shortage of donor organs is the main limiting factor for successful …

For many patients with terminal/advanced cardiac failure, heart transplantation is the most
effective, durable treatment option, and offers the best prospects for a high quality of life. The …

The steady progress in genome editing, especially genome editing based on the use of
clustered regularly interspaced short palindromic repeats (CRISPR) and programmable …