Applying the Bradford Hill criteria for causation to repetitive head impacts and chronic traumatic encephalopathy

CJ Nowinski, SC Bureau, ME Buckland… - Frontiers in …, 2022 - frontiersin.org
Chronic traumatic encephalopathy (CTE) is a neurodegenerative disease associated with a
history of repetitive head impacts (RHI). CTE was described in boxers as early as the 1920s …

Military traumatic brain injury: a challenge straddling neurology and psychiatry

LZ Kong, RL Zhang, SH Hu, JB Lai - Military medical research, 2022 - Springer
Military psychiatry, a new subcategory of psychiatry, has become an invaluable, intangible
effect of the war. In this review, we begin by examining related military research …

Saffron extract and crocin exert anti-inflammatory and anti-oxidative effects in a repetitive mild traumatic brain injury mouse model

M Salem, M Shaheen, A Tabbara, J Borjac - Scientific Reports, 2022 - nature.com
Abstract Saffron Crocus sativus L.(C. sativus) is a flower from the iridaceous family. Crocin,
saffron's major constituent, and saffron have anti-oxidative and anti-inflammatory activities …

A critical appraisal of tau‐targeting therapies for primary and secondary tauopathies

BP Imbimbo, S Ippati, M Watling… - Alzheimer's & …, 2022 - Wiley Online Library
Introduction Primary tauopathies are neurological disorders in which tau protein deposition
is the predominant pathological feature. Alzheimer's disease is a secondary tauopathy with …

Neuropathology in chronic traumatic encephalopathy: a systematic review of comparative post-mortem histology literature

HC Murray, C Osterman, P Bell, L Vinnell… - Acta Neuropathologica …, 2022 - Springer
Chronic traumatic encephalopathy (CTE) is a neurodegenerative disease associated with
repetitive head trauma and is characterised by the perivascular accumulation of …

Association between single moderate to severe traumatic brain injury and long-term tauopathy in humans and preclinical animal models: a systematic narrative review …

A Walker, B Chapin, J Abisambra… - Acta neuropathologica …, 2022 - Springer
Background The initiation, anatomic pattern, and extent of tau spread in traumatic brain
injury (TBI), and the mechanism by which TBI leads to long-term tau pathology, remain …

Fetuin-A alleviates neuroinflammation against traumatic brain injury-induced microglial necroptosis by regulating Nrf-2/HO-1 pathway

P Zhao, Y Wei, G Sun, L Xu, T Wang, Y Tian… - Journal of …, 2022 - Springer
Background The microglia-mediated inflammatory response is a vital mechanism of
secondary damage following traumatic brain injury (TBI), but the underlying mechanism of …

Earlier Detection of Alzheimer's Disease Based on a Novel Biomarker cis P-tau by a Label-Free Electrochemical Immunosensor

A Shiravandi, F Yari, N Tofigh, M Kazemi Ashtiani… - Biosensors, 2022 - mdpi.com
Early detection of cis phosphorylated tau (cis P-tau) may help as an effective treatment to
control the progression of Alzheimer's disease (AD). Recently, we introduced for the first time …

Hippocampal cells segregate positive and negative engrams

M Shpokayte, O McKissick, X Guan, B Yuan… - Communications …, 2022 - nature.com
The hippocampus is involved in processing a variety of mnemonic computations specifically
the spatiotemporal components and emotional dimensions of contextual memory. Recent …

Targeting tau only extracellularly is likely to be less efficacious than targeting it both intra-and extracellularly

EE Congdon, Y Jiang, EM Sigurdsson - Seminars in cell & developmental …, 2022 - Elsevier
Aggregation of the tau protein is thought to be responsible for the neurodegeneration and
subsequent functional impairments in diseases that are collectively named tauopathies …