MAPK cascades and transcriptional factors: regulation of heavy metal tolerance in plants

S Li, X Han, Z Lu, W Qiu, M Yu, H Li, Z He… - International Journal of …, 2022 - mdpi.com
In nature, heavy metal (HM) stress is one of the most destructive abiotic stresses for plants.
Heavy metals produce toxicity by targeting key molecules and important processes in plant …

[HTML][HTML] Modulation of reactive oxygen species to overcome 5-fluorouracil resistance

KS Chun, SH Joo - Biomolecules & Therapeutics, 2022 - ncbi.nlm.nih.gov
Fluorouracil (5-FU) remains to be an important chemotherapeutic drug for treating several
cancers when targeted therapy is unavailable. Chemoresistance limits the clinical utility of 5 …

Melatonin prevents UVB-induced skin photoaging by inhibiting oxidative damage and MMP expression through JNK/AP-1 signaling pathway in human dermal …

M Yuksel Egrilmez, S Kocturk, S Aktan, G Oktay… - Life, 2022 - mdpi.com
Exposure to ultraviolet (UV) irradiation causes damage to the skin and induces photoaging.
UV irradiation stimulates production of reactive oxygen/nitrogen species, which results in …

[HTML][HTML] Cineole alleviates the BPA-inhibited NETs formation by regulating the p38 pathway-mediated programmed cell death

L Chen, D Tao, M Qi, T Wang, Z Jiang, S Xu - … and environmental safety, 2022 - Elsevier
Bisphenol A (BPA) is an endocrine disruptor, that can cause immune dysfunction. Cineole
(CIN) has that effect of regulating immune function and resist oxidation. Neutrophil …

Eriocitrin, a dietary flavonoid suppressed cell proliferation, induced apoptosis through modulation of JAK2/STAT3 and JNK/p38 MAPKs signaling pathway in MCF‐7 …

C Yuan, G Chen, C Jing, M Liu, B Liang… - … of Biochemical and …, 2022 - Wiley Online Library
Eriocitrin, a lemons flavanone, exhibits several biological properties, antiproliferative, and
proapoptotic effects. However, its molecular mechanical action is not entirely clarified …

Selenium nanoparticles alleviate lead acetate‐induced toxicological and morphological changes in rat testes through modulation of calmodulin‐related genes …

YM El‐fakharany, EM Mohamed… - … of biochemical and …, 2022 - Wiley Online Library
Lead (Pb) is one of the most common toxic heavy metals. It is a well‐known testicular
toxicant. Selenium nanoparticles (SeNPs) are a more effective form of elemental selenium …

Protective effects of the postbiotic deriving from cow's milk fermentation with L. paracasei CBA L74 against Rotavirus infection in human enterocytes

C Bruno, L Paparo, L Pisapia, A Romano, M Cortese… - Scientific Reports, 2022 - nature.com
Rotavirus (RV) is the leading cause of acute gastroenteritis-associated mortality in early
childhood. Emerging clinical evidence suggest the efficacy of the postbiotic approach based …

[HTML][HTML] Sargahydroquinoic acid isolated from Sargassum serratifolium as inhibitor of cellular basophils activation and passive cutaneous anaphylaxis in mice

KS Choi, TS Shin, J Chun, G Ahn, EJ Han… - International …, 2022 - Elsevier
Basophils and mast cells are characteristic effector cells in allergic reactions.
Sargahydorquinoic acid (SHQA), a compound isolated from Sargassum serratifolium …

Matrix metalloproteinase-7 induces E-cadherin cleavage in acid-exposed primary human pharyngeal epithelial cells via the ROS/ERK/c-Jun pathway

NR Im, B Kim, KY Jung, SK Baek - Journal of Molecular Medicine, 2022 - Springer
Laryngopharyngeal reflux disease (LPRD) is caused by pharyngeal mucosal damage due to
the reflux of gastric contents, including acid, pepsin, and bile juice. Our previous study has …

The mechanisms of glycolipid metabolism disorder on vascular injury in type 2 diabetes

X Chen, C Shi, Y Wang, H Yu, Y Zhang… - Frontiers in …, 2022 - frontiersin.org
Patients with diabetes have severe vascular complications, such as diabetic nephropathy,
diabetic retinopathy, cardiovascular disease, and neuropathy. Devastating vascular …