Over the past decade, substantial progress has been made in the discovery of alleles
contributing to the risk of coronary artery disease. In addition to providing causal insights into …

The exclusive expression of uromodulin in the kidneys has made it an intriguing protein in
kidney and cardiovascular research. Genome-wide association studies discovered variants …

Numerous genes for monogenic kidney diseases with classical patterns of inheritance, as
well as genes for complex kidney diseases that manifest in combination with environmental …

Uromodulin (UMOD) is a major risk gene for monogenic and complex forms of kidney
disease. The encoded kidney-specific protein uromodulin is highly abundant in urine and …

Recent compelling results indicate possible links between neurotransmitters, intestinal
mucosal IgA+ B cell responses, and immunoglobulin A nephropathy (IgAN) pathogenesis …

Background Uromodulin, the most abundant protein excreted in normal urine, plays major
roles in kidney physiology and disease. The mechanisms regulating the urinary excretion of …

Uremic toxins are a heterogeneous group of molecules that accumulate in the body due to
the progression of chronic kidney disease (CKD). These toxins are associated with kidney …

Adiponectin, encoded by ADIPOQ, is an insulin-sensitizing, anti-inflammatory, and
renoprotective adipokine that activates receptors with intrinsic ceramidase activity. We …

Background: The common non-synonymous mutation of the glucokinase regulator (GCKR)
gene, namely rs1260326, is widely reported to have pleiotropic effects on cardio-metabolic …

Hypertension and kidney disease have been repeatedly associated with genomic variants
and alterations of lysine metabolism. Here, we combined stable isotope labeling with …