A coumarin coupled tetraphenylethylene based AIEgen (TPE-Lac) with an intense greenish-
yellow emission has been synthesized and utilized for multipurpose sensing and imaging …

We recently established the mechanism-based inactivation (MBI) of cytochrome P450 3A
(CYP3A) by the fibroblast growth factor receptor (FGFR) inhibitors erdafitinib and infigratinib …

This year's review on bioactivation and reactivity began as a part of the annual review on
biotransformation and bioactivation led by Cyrus Khojasteh (see references). Increased …

Masitinib is a small molecule tyrosine kinase inhibitor under investigation for the treatment of
amyotrophic lateral sclerosis, mastocytosis, and COVID-19. Hepatotoxicity has been …

Samples containing cyanide were incubated at 85° C in the presence of the fluorogenic
reagent 3-(2-furoyl) quinoline-2-carboxaldehyde (FQ) and glutamic acid, and analyzed by …

Xenobiotics in Chemical Carcinogenesis: Translational Aspects in Toxicology covers the
translational toxicology of xenobiotics substances in carcinogenesis by explaining the …

Understanding clinical drug–drug interaction (DDI) risks which are a result of inhibition of
major human cytochrome P450 enzymes is a critical activity associated with drug …

This chapter deals with the mechanisms involved in the biotransformation of drugs to
chemically reactive metabolites, the current experimental techniques used to identify …