Polypharmacology breaks up the classical paradigm of “one-drug, one target, one disease”
electing multitarget compounds as potential therapeutic tools suitable for the treatment of …

The prefrontal cortex plays a central role in the control of complex cognitive processes
including action control and decision making. It also shows a specific pattern of delayed …

Normal development and function of the central nervous system involves a balance between
excitatory and inhibitory neurotransmission. Activity of both excitatory and inhibitory neurons …

The adaptor protein complex AP-4 mediates anterograde axonal transport and is essential
for axon health. AP-4-deficient patients suffer from a severe neurodevelopmental and …

The hypothalamus is an evolutionarily conserved endocrine interface that, among other
roles, links central homeostatic control to adaptive bodily responses by releasing hormones …

The endocannabinoids 2‐arachidonoylglycerol (2‐AG) and anandamide are among the
best studied lipid messengers in the brain. By activating cannabinoid receptors in the CNS …

The endocannabinoid system (ECS) regulates brain development and function, energy
metabolism and stress in a sex-, age-and tissue-dependent manner. The ECS comprises …

Cannabis use during pregnancy has increased over the past few decades, with recent data
indicating that, in youth and young adults especially, up to 22% of people report using …

The influence of cannabidiol (CBD) on brain development is inadequately understood.
Since CBD is considered a non-intoxicating drug, it has attracted great interest concerning …

Recent years have seen an impressive amount of research devoted to understanding the
etiopathology of Autism Spectrum Disorder (ASD) and developing therapies for this …