The absorption of orally administered drug products is a complex, dynamic process,
dependant on a range of biopharmaceutical properties; notably the aqueous solubility of a …

Among various drug administration routes, oral drug delivery is preferred and is considered
patient-friendly; hence, most of the marketed drugs are available as conventional tablets or …

Minimizing in vitro and in vivo testing in early drug discovery with the use of physiologically
based pharmacokinetic (PBPK) modeling and machine learning (ML) approaches has the …

Vitamin D3 deficiency has serious health consequences, as demonstrated by its effect on
severity and recovery after COVID-19 infection. Because of high hydrophobicity, its …

Abstract The Simcyp Simulator is a software platform for population physiologically‐based
pharmacokinetic (PBPK) modeling and simulation. It links in vitro data to in vivo absorption …

Computational methods assisting drug discovery and development are routine in the
pharmaceutical industry. Digital recording of ADMET assays has provided a rich source of …

Perinatal pharmacology is influenced by a myriad of physiological variables that are
changing dynamically. The influence of these covariates has not been assessed …

Abstract Backgrond and Objective Crohn's disease (CD) is a chronic inflammatory bowel
disease that affects a wide age range. Hence, CD patients receive a variety of drugs over …

The volume and distribution of fluids available in the gastrointestinal (GI) tract may
substantially affect oral drug absorption. Magnetic resonance imaging (MRI) has been used …

While the concept of 'Virtual Bioequivalence'(VBE) using a combination of modelling, in vitro
tests and integration of pre-existing data on systems and drugs is growing from its infancy …