Cyclic peptides are among the most diverse architectures for current drug discovery efforts.
Their size, stability, and ease of synthesis provide attractive scaffolds to engage and …

Neurodegenerative diseases (NDs) are described as multifactorial and progressive
syndromes with compromised cognitive and behavioral functions. The multi-target-directed …

We have carried out the design, synthesis, and evaluation of a small library of 2-
aminobenzoxazole-appended coumarins as novel inhibitors of tumour-related CAs IX and …

Growing evidence indicates that brain carbonic anhydrases (CAs) are key modulators in
cognition, particularly in recognition and aversive memories. Here we described a role for …

Alzheimer disease (AD) is a leading cause of dementia that has gained prominence in our
aging society. Yet, the complexity of diagnosing AD and measuring its invasiveness poses …

In this study, novel silicon (IV) phthalocyanines (SiPcs) containing 4-hydroxypyridine (1a), N-
(2-hydroxyethyl) succinimide (2a) and N-(2-hydroxyethyl) phthalimide (3a) at their axial …

Proteins are able to irreversibly assemble biologically active ligands from building blocks
bearing complementary reactive functions due their spatial proximity, through a kinetic target …

La presente Tesis Doctoral, desarrollada en cotutela entre los grupos de investigación
Síntesis y Modificación de Productos Naturales (Benemérita Universidad Autónoma de …

El ácido oleanólico (OA, ácido 3β-hidroxiolean-12-en-28-oico, Figura 6.1) es un
triterpenoide pentacíclico biológicamente activo y bastante común en la naturaleza, donde …

Stroke is a cerebrovascular disease affecting blood supply to the brain. With an incidence of
approximately 240 per 100.000 and a mortality of about 30%(Grysiewicz et al., 2008), brain …