Autoimmunity is caused by an unbalanced immune system, giving rise to a variety of organ-
specific to system disorders. Patients with autoimmune diseases are commonly treated with …

The importance of regulatory T cells (Tregs) in preventing autoimmunity has been well
established; however, the precise alterations in Treg function in autoimmune individuals and …

Regulatory T-cells (Treg) are critical for the maintenance of immune homeostasis and
tolerance induction. While the immunosuppressive mechanisms of Treg have been …

Blood vessels are indispensable for host survival and are protected from inappropriate
inflammation by immune privilege. This protection is lost in patients with autoimmune …

Simple Summary Antibodies directed at so-called immune checkpoint molecules represent a
substantial improvement in cancer therapy. These biological reagents highlight the exquisite …

Abstract CD4+ Foxp3+ Regulatory T cells (Tregs) are essential for maintaining self-tolerance
and are increasingly recognised to have important roles in tissue homeostasis and repair. In …

Abstract CD4+ Foxp3+ regulatory T cells (Tregs), a subpopulation of CD4+ T cells, are
engaged in maintaining the periphery tolerance and preventing autoimmunity. Recent …

Regulatory T (Treg) cells are critical for the maintenance of immune homeostasis.
Dysregulation of Treg cells has been implicated in the pathogenesis of autoimmunity and …

The role of CD4 T regulatory cells is well established in peripheral tolerance and the
pathogenesis of the murine model and human autoimmune diseases. CD4 T regulatory cells …

Simple Summary Colorectal cancer is one of the leading causes of global cancer-related
mortality. Tumor-infiltrating effector immune cells play critical roles in tumor control, and their …