The robustness of cellular immunity determines the fate of SARS-CoV-2 infection

E Moga, E Lynton-Pons, P Domingo - Frontiers in immunology, 2022 - frontiersin.org
Two years after the appearance of the SARS-CoV-2 virus, the causal agent of the current
global pandemic, it is time to analyze the evolution of the immune protection that infection …

IgG anti-spike antibodies and surrogate neutralizing antibody levels decline faster 3 to 10 months after BNT162b2 vaccination than after SARS-CoV-2 infection in …

B Decru, J Van Elslande, S Steels… - Frontiers in …, 2022 - frontiersin.org
Background IgG anti-spike (S) antibodies arise after SARS-CoV-2 infection as well as
vaccination. Levels of IgG anti-S are linked to neutralizing antibody titers and protection …

Specific anti-SARS-CoV-2 humoral and cellular immune responses after booster dose of BNT162b2 pfizer-BioNTech mRNA-based vaccine: Integrated study of …

R Busà, MC Sorrentino, G Russelli, G Amico… - Frontiers in …, 2022 - frontiersin.org
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), which causes coronavirus
disease 2019 (COVID-19), is modifying human activity all over the world with significant …

Clinical and immunological features of SARS-CoV-2 breakthrough infections in vaccinated individuals requiring hospitalization

G Lamacchia, A Mazzoni, M Spinicci, A Vanni… - Journal of Clinical …, 2022 - Springer
Abstract Background and Purpose Waning immunity and the surge of SARS-CoV-2 variants
are responsible for breakthrough infections, ie, infections in fully vaccinated individuals …

Humoral and cellular immune response over 9 months of mRNA-1273, BNT162b2 and ChAdOx1 vaccination in a University Hospital in Spain

L Fernández-Ciriza, Á González, JL Del Pozo… - Scientific Reports, 2022 - nature.com
Scarce data have been reported about cellular immunity and longevity for different COVID-
19 vaccination schedules. We carried out a prospective study enrolling 709 healthcare …

Memory B cells and memory T cells induced by SARS-CoV-2 booster vaccination or infection show different dynamics and responsiveness to the omicron variant

S Mise-Omata, M Ikeda, M Takeshita… - The Journal of …, 2022 - journals.aai.org
Although the immunological memory produced by BNT162b2 vaccination against severe
acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has been well studied and …

Durability and cross-reactivity of immune responses induced by a plant-based virus-like particle vaccine for COVID-19

P Gobeil, S Pillet, I Boulay, N Charland, A Lorin… - Nature …, 2022 - nature.com
As the SARS-CoV-2 pandemic evolves, vaccine evaluation needs to include consideration
of both durability and cross-reactivity. This report expands on previously reported results …

Role of booster with BNT162b2 mRNA in SARS-CoV-2 vaccination in patients with rheumatoid arthritis

M Benucci, A Damiani, FL Gobbi, B Lari, V Grossi… - Immunologic …, 2022 - Springer
Only case reports and small clinical series report the effects of booster vaccination with
BNT162b2 in patients with rheumatoid arthritis (RA). We studied 200 patients with RA in …

Current understanding of T cell immunity against SARS-CoV-2

X Lu, S Yamasaki - Inflammation and Regeneration, 2022 - Springer
As an important part of adaptive immunity, T cells are indispensable in the defense against
pathogens including viruses. SARS-CoV-2 is a new human coronavirus that occurred at the …

Fourth dose of mRNA COVID-19 vaccine transiently reactivates spike-specific immunological memory in people living with HIV (PLWH)

G Lamacchia, L Salvati, ST Kiros, A Mazzoni, A Vanni… - Biomedicines, 2022 - mdpi.com
Background: People Living With HIV (PLWH), with advanced disease, lower CD4+ T cell
counts or an unsuppressed HIV viral load can have a suboptimal vaccine response. For this …