ApoE is the major lipid and cholesterol carrier in the CNS. There are three major human
polymorphisms, apoE2, apoE3, and apoE4, and the genetic expression of APOE4 is one of …

Abstract Coronavirus disease 2019 (COVID-19), which is caused by severe acute
respiratory syndrome coronavirus 2 (SARS-CoV-2), is a life-threatening disease, especially …

Dementia is more prevalent in Blacks than in Whites, likely due to a combination of
environmental and biological factors. Paradoxically, clinical studies suggest an attenuation …

The heritability of Alzheimer's disease estimated from twin studies is greater than the
heritability derived from genome-based studies, for reasons that remain unclear. We apply …

Background Considerable overlap exists between the risk factors of dementia and cerebral
small vessel disease (SVD). However, studies remain limited to older cohorts wherein …

The human apolipoprotein E4 isoform (APOE4) is the strongest genetic risk factor for late-
onset Alzheimer's disease (AD), and lysosomal dysfunction has been implicated in AD …

Type 2 diabetes mellitus and Alzheimer's disease (AD), both are chronic and progressive
diseases. Many cardiovascular and genetic risk factors are considered responsible for the …

Dementia, in particular, is a defining feature of Alzheimer's and Parkinson's diseases.
Because of the combination of motor and cognitive impairments, Parkinson's disease …

The relationship between APOE polymorphisms and Parkinson's disease (PD) in black
Africans has not been previously investigated. We evaluated the association between APOE …

With growing and ageing populations, the incidence of dementia is expected to triple
globally by 2050. In the absence of effective drugs to treat or reverse the syndrome, dietary …