This review presents an overview of the available literature regarding intranasal
corticosteroids (INCs) for the treatment of allergic rhinitis (AR). Various treatment options …

Acetylcholinesterase inhibitors are the most used drugs to manage Alzheimer's disease,
although they show low bioavailability in the brain. In this sense, nasal administration has …

Validating numerical models against experimental models of nasal spray deposition is
challenging since many aspects must be considered. That being said, it is a critical step in …

Background: While the nasopharynx is initially the dominant upper airway infection site for
SARS-CoV-2, the physiologic mechanism launching the infection at the lower airway is still …

To improve the relationships between commonly conducted in vitro studies for locally-acting
nasal spray drug products with in vivo regional deposition, this study developed a set of in …

Various factors and challenges are involved in efficiently delivering drugs using nasal
sprays to the olfactory region to treat central nervous system diseases. In this study …

Recent advances in in vitro and in silico methods provide a number of opportunities for
better characterization of inhaled pharmaceutical aerosol performance in early drug …

The blood–brain barrier is a highly selective semipermeable border that separates blood
circulation from the brain and hinders the accumulation of substances in the central nervous …

The overarching theme of this work is the investigation and development of in vitro and in
silico methods used to characterize inhaled pharmaceutical aerosols. The ultimate aim is to …

The objective of this thesis is to describe two new methodologies for evaluating medical gas
and nasal spray delivery, respectively, in vitro using nasal replicas. The first half of the body …