Learning to be elite: Lessons from HIV-1 controllers and animal models on trained innate immunity and virus suppression

S Sugawara, RK Reeves, S Jost - Frontiers in Immunology, 2022 - frontiersin.org
Although antiretroviral therapy (ART) has drastically changed the lives of people living with
human immunodeficiency virus-1 (HIV-1), long-term treatment has been associated with a …

Immunogenomics of killer cell immunoglobulin-like receptor (KIR) and HLA class I: coevolution and consequences for human health

NR Pollock, GF Harrison, PJ Norman - The Journal of Allergy and Clinical …, 2022 - Elsevier
Interactions of killer cell immunoglobin-like receptors (KIR) with human leukocyte antigens
(HLA) class I regulate effector functions of key cytotoxic cells of innate and adaptive …

Host KIR/HLA-c genotypes determine HIV-mediated changes of the NK cell repertoire and are associated with vpu sequence variations impacting downmodulation of …

S Vollmers, A Lobermeyer, A Niehrs, P Fittje… - Frontiers in …, 2022 - frontiersin.org
NK cells play a pivotal role in viral immunity, utilizing a large array of activating and inhibitory
receptors to identify and eliminate virus-infected cells. Killer-cell immunoglobulin-like …

Does the Interaction of KIR and HLA Affect the Development of Non-Infectious Uveitis?

J Nakamura, M Takeuchi, M Ota… - Current Molecular …, 2022 - ingentaconnect.com
Immune tolerance is established in the eye to prevent permanent blindness associated with
destructive damage to the cornea and retina caused by immune cell infiltration; hence, the …

Allele imputation for the killer cell immunoglobulin-like receptor KIR3DL1/S1

GF Harrison, LA Leaton, EA Harrison… - PLoS Computational …, 2022 - journals.plos.org
Highly polymorphic interaction of KIR3DL1 and KIR3DS1 with HLA class I ligands
modulates the effector functions of natural killer (NK) cells and some T cells. This genetically …

[HTML][HTML] Epitope length variants balance protective immune responses and viral escape in HIV-1 infection

P Pymm, S Tenzer, E Wee, M Weimershaus… - Cell reports, 2022 - cell.com
Cytotoxic T lymphocyte (CTL) and natural killer (NK) cell responses to a single optimal 10-
mer epitope (KK10) in the human immunodeficiency virus type-1 (HIV-1) protein p24Gag are …

Polymorphic KIR3DL3 expression modulates tissue-resident and innate-like T cells

WH Palmer, LA Leaton, AC Codo, PS Hume, B Crute… - Biorxiv, 2022 - biorxiv.org
Most human killer cell immunoglobulin-like receptors (KIR) are expressed by Natural Killer
(NK) cells and recognize HLA class I molecules as ligands. Uniquely, KIR3DL3 is a …

Epitope characterization of a monoclonal antibody that selectively recognizes KIR2DL1 allotypes

M Falco, R Meazza, C Alicata, P Canevali, A Muntasell… - Hla, 2022 - Wiley Online Library
Killer immunoglobulin‐like receptor (KIR) genes code for a family of inhibitory and activating
receptors, finely tuning NK cell function. Numerous studies reported the relevance of KIR …