Glycomics aims to identify the structure and function of the glycome, the complete set of
oligosaccharides (glycans), produced in a given cell or organism, as well as to identify …

The presence of fucose on IgG1 Asn-297 N-linked glycan is the modification of the human
IgG1 Fc structure with the most significant impact on FcɣRIII affinity. It also significantly …

Post-translational modifications diversify protein functions and dynamically coordinate their
signalling networks, influencing most aspects of cell physiology. Nevertheless, their genetic …

Purpose Chronic low back pain (cLBP) is a common health condition worldwide and a
leading cause of disability with an estimated lifetime prevalence of 80–90% in industrialized …

In-depth multiomics phenotyping can provide a molecular understanding of complex
physiological processes and their pathologies. Here, we report on the application of 18 …

Lumbar intervertebral disc degeneration (DD) disease is one of the main risk factors for low
back pain and a leading cause of population absenteeism and disability worldwide. Despite …

Being one of the most dynamic entities in the human body, glycosylation of proteins fine-
tunes the activity of the organismal machinery, including the immune system, and mediates …

Post-traumatic stress disorder (PTSD) is a complex trauma-related disorder, the etiology and
underlying molecular mechanisms of which are still unclear and probably involve different …

It is often difficult to be certain which genes underlie the effects seen in association studies.
However, variants that disrupt the protein, such as predicted loss of function (pLoF) and …

N-glikozilacija proteina plazme povezana je s komplikacijama šećerne bolesti tipa 1, dok je
uloga ove enzimske modifikacije proteina u nastanku same bolesti neistražena. S razvojem …