[HTML][HTML] Perspectives and mechanisms for targeting ferroptosis in the treatment of hepatocellular carcinoma

L Li, X Wang, H Xu, X Liu, K Xu - Frontiers in Molecular Biosciences, 2022 - frontiersin.org
Ferroptosis is a novel process of regulated cell death discovered in recent years, mainly
caused by intracellular lipid peroxidation. It is morphologically manifested as shrinking of …

[HTML][HTML] HypoxaMIRs: key regulators of hallmarks of colorectal cancer

J Coronel-Hernández, I Delgado-Waldo… - Cells, 2022 - mdpi.com
Hypoxia in cancer is a thoroughly studied phenomenon, and the logical cause of the
reduction in oxygen tension is tumor growth itself. While sustained hypoxia leads to death by …

[HTML][HTML] Circulating miRNA expression profiles and machine learning models in association with response to irinotecan-based treatment in metastatic colorectal …

E Pliakou, DI Lampropoulou, N Dovrolis… - International Journal of …, 2022 - mdpi.com
Colorectal cancer represents a leading cause of cancer-related morbidity and mortality.
Despite improvements, chemotherapy remains the backbone of colorectal cancer treatment …

[HTML][HTML] miR-181b regulates vascular endothelial aging by modulating a MAP3K3 signaling pathway

H Zhou, D Yang, HS Cheng, MG McCoy… - … : official publication of …, 2022 - ncbi.nlm.nih.gov
Endothelial cell (EC) aging plays a vital role in the pathogenesis of cardiovascular disease
(CVD). MicroRNAs have emerged as crucial regulators of target gene expression by …

[HTML][HTML] Interplay between non-coding RNAs and programmed cell death proteins

S Ghafouri-Fard, BM Hussen, M Mohaqiq… - Frontiers in …, 2022 - frontiersin.org
Programmed cell death (PDCD) family of proteins includes at least 12 members, function of
seven of them being more investigated. These members are PDCD1, PDCD2, PDCD4 …

LncSNHG1 Promoted CRC Proliferation through the miR‐181b‐5p/SMAD2 Axis

Q Huang, Z Yang, J Tian, P You, J Wang… - Journal of …, 2022 - Wiley Online Library
Objective. To investigate the effects of LncRNA SNHG1 on the proliferation, migration, and
epithelial‐mesenchymal transition (EMT) of colorectal cancer cells (CRCs). Methods. 4 pairs …

[HTML][HTML] The role and interactions of programmed cell death 4 and its regulation by microRNA in transformed cells of the gastrointestinal tract

WF Ferris - Frontiers in Oncology, 2022 - frontiersin.org
Data from GLOBOCAN 2020 estimates that there were 19.3 million new cases of cancer and
10.0 million cancer-related deaths in 2020 and that this is predicted to increase by 47% in …

Long noncoding RNA LINC01426 promotes the progression of lung adenocarcinoma via regulating miRNA-125a-5p/casein kinase 2 alpha 1 axis

X Zhu, J Zhao, J Xu - Bioengineered, 2022 - Taylor & Francis
Although long noncoding RNAs (lncRNAs) in lung adenocarcinoma (LUAD) have been
increasingly studied, LINC01426 has not been fully investigated in LUAD. The GEPIA …

[HTML][HTML] From inflammatory bowel disease to colorectal cancer: what's the role of miRNAs?

M Vaghari-Tabari, N Targhazeh, S Moein… - Cancer Cell …, 2022 - Springer
Abstract Inflammatory Bowel Disease (IBD) is a chronic inflammatory disease with relapse
and remission periods. Ulcerative colitis and Crohn's disease are two major forms of the …

miR-181b promotes the oncogenesis of renal cell carcinoma by targeting TIMP3.

Y Zou, L Zhang, X Zhong - Biocell, 2022 - search.ebscohost.com
Renal cell carcinoma (RCC) has a poor prognosis due to limited diagnosis and treatment.
Thus, it is necessary to find novel prognostic biomarkers and therapeutic targets. The …