Major depressive disorder is a highly debilitating psychiatric disorder involving the
dysfunction of different cell types in the brain. Microglia are the predominant resident …

Aims The family of kynurenine pathway (KP) metabolites includes compounds produced
along two arms of the path and acting in clearly opposite ways. The equilibrium between …

Depression is a debilitating mental disorder that affects> 322 million people worldwide.
Despite the availability of several antidepressant agents, many patients remain treatment …

Kynurenine pathway is the main route of tryptophan metabolism and produces several
metabolites with various biologic properties. It has been uncovered that several …

Under normal physiological conditions, the kynurenine pathway (KP) plays a critical role in
generating cellular energy and catabolizing tryptophan. Under inflammatory conditions …

Abstract l-tryptophan, an essential amino acid, regulates protein homeostasis and plays a
role in neurotransmitter-mediated physiological events. It also influences age-associated …

Microbial metabolites affect the neuron system and muscle cell functions. Amyotrophic
lateral sclerosis (ALS) is a multifactorial neuromuscular disease. Our previous study has …

Kynurenine 3-monooxygenase (KMO), a key player in the kynurenine pathway (KP) of
tryptophan degradation, regulates the synthesis of the neuroactive metabolites 3 …

REL-1017 (esmethadone) is a novel N-methyl-D-aspartate receptor (NMDAR) antagonist
and promising rapid antidepressant candidate. Using fluorometric imaging plate reader …

Tryptophan (Trp) metabolism through the kynurenine pathway (KP) is well known to play a
critical function in cancer, autoimmune and neurodegenerative diseases. However, its role …