Aging induces a series of immune related changes, which is called immunosenescence,
playing important roles in many age-related diseases, especially neurodegenerative …

Aging is the greatest risk factor for nearly all major chronic diseases, including
cardiovascular diseases, cancer, Alzheimer's and other neurodegenerative diseases of …

The decline of CD8+ T cell functions contributes to deteriorating health with aging, but the
mechanisms that underlie this phenomenon are not well understood. We use single-cell …

Aging is a major risk factor for developing severe COVID-19, but few detailed data are
available concerning immunological changes after infection in aged individuals. Here we …

Cellular senescence is characterized by irreversible cell cycle arrest in response to different
triggers and an inflammatory secretome. Although originally described in fibroblasts and cell …

Nowadays, aging is understood as a dynamic and multifaceted dysregulation process that
spares almost no human organ or cell. The immune system being among the most affected …

Dogs are remarkable, adaptable, and dependable creatures that have evolved alongside
humans while contributing tremendously to our survival. Our canine companions share …

Centenarians, who show mild infections and low incidence of tumors, are the optimal model
to investigate healthy aging. However, longevity related immune characteristics has not …

Problem Many studies have demonstrated the negative impact of high rates of NK
cytotoxicity (NKc) on reproductive processes, but there is no agreement as to the …

Pneumonia is a common reason for admission afflicting frail older adults. Those who are the
frailest are more likely to be provided with a diagnosis of aspiration pneumonia. This …