Extracellular vesicles (EVs) are cell-derived membrane-enclosed particles that are involved
in physiologic and pathologic processes. EVs are increasingly being studied for therapeutic …

The most recent and non-invasive approach for studying early-stage biomarkers is liquid
biopsy. This implies the extraction and analysis of non-solid biological tissues (serum …

Exosomes transport a variety of macromolecules and modulate intercellular communication
in physiology and disease. However, the regulation mechanisms that determine exosome …

Extracellular vesicles (EVs) are emerging as key mediators of cell-to-cell communications
and signal transporters between tumor and stroma, and hypoxia is a critical characteristic of …

Mesenchymal stem/stromal cells (MSCs) are multipotent somatic cells that have been widely
explored in the field of regenerative medicine. MSCs possess the ability to secrete soluble …

Extracellular vesicles (EVs) play a pivotal role in intercellular communication and have been
implicated in cancer progression. Hypoxia, a pervasive hallmark of cancer, is known to …

Adenylate kinase (AK) regulates adenine nucleotide metabolism and catalyzes the ATP+
AMP⇌ 2ADP reaction in a wide range of organisms and bacteria. AKs regulate adenine …

Esophageal squamous cell carcinoma (ESCC) remains one of the most lethal and
widespread malignancies in China. Exosomes, a subset of tiny extracellular vesicles …

Aims The biological functions of colorectal cancer (CRC) cell derived exosomes responding
to hypoxic microenvironment and its underlying mechanisms remain unclear. Main methods …

Metastatic uveal melanoma remains incurable at present. We previously demonstrated that
loss of BAP1 gene expression in tumour cells triggers molecular mechanisms of …