Microglia activation is observed in various neurodegenerative diseases. Recent advances in
single-cell technologies have revealed that these reactive microglia were with high spatial …

Aging is a complex process that produces profound effects on the brain. Although a number
of external factors can promote the initiation and progression of brain aging, peripheral and …

Parkinson's disease (PD) is a widespread neurodegenerative condition affecting millions
globally. This investigation centered on the gut-brain axis in a rotenone-induced PD rat …

Parkinson's disease is a progressive neurodegenerative disorder that is associated with
motor and nonmotor symptoms. Accumulation of misfolded α-synuclein is considered a key …

Pathogenic forms of α-synuclein (α-syn) are transferred to and from neurons, astrocytes, and
microglia, which spread α-syn pathology in the olfactory bulb and the gut and then …

Parkinson's Disease (PD), the second most common neurodegenerative disorder, is
characterised by the severe loss of dopaminergic neurons in the Substantia Nigra pars …

Background In the last decades different preclinical animal models of Parkinson's disease
(PD) have been generated, aiming to mimic the progressive neuronal loss of midbrain …

Parkinson's Disease (PD), the second most common neurodegenerative disorder, is
characterized by the severe loss of dopaminergic neurons in the Substantia Nigra pars …

In dieser Arbeit wurde die Krankheitsprogression im Parkinson-Mausmodell hm2α-SYN-39
mit zunehmendem Alter charakterisiert. Die Mäuse wurden in 4 Altersgruppen (2-3, 7-8, 11 …