Quantitative traits are often complex because of the contribution of many loci, with further
complexity added by environmental factors. In medical research, systems genetics is a …

Cardiometabolic diseases encompass a range of interrelated conditions that arise from
underlying metabolic perturbations precipitated by genetic, environmental, and lifestyle …

The complexity of many cellular and organismal traits results from the integration of genetic
and environmental factors via molecular networks. Network structure and effect propagation …

Gene co-expression analysis has emerged as a powerful method to provide insights into
gene function and regulation. The rapid growth of publicly available RNA-sequencing (RNA …

Network medicine has improved the mechanistic understanding of disease, offering
quantitative insights into disease mechanisms, comorbidities, and novel diagnostic tools and …

Introduction Sterol regulatory element binding protein (SREBP) cleavage-associating
protein (SCAP) is a sterol-regulated escort protein that translocates SREBPs from the …

Background Numerous studies have reported the vital roles of circular RNA (circRNA)-
based competitive endogenous RNA (ceRNA) regulatory networks in cancers. Here, we …

Technological advancement, data democratisation, and decreasing costs have led to a
revolution in molecular biology in which the entire set of DNA, RNA, proteins, and various …

Metabolic reprogramming plays a pivotal role in the differentiation and function of immune
cells including dendritic cells (DCs). Regulatory DCs can be generated in regional tissue …

Expression quantitative trait locus detection has become increasingly important for
understanding how noncoding variants contribute to disease susceptibility and complex …