Physical activity, including walking, has numerous health benefits in older adults, supported
by a plethora of observational and interventional studies. Walking decreases the risk or …

Sirtuins are NAD+-dependent protein lysine deacylases and mono-ADP-ribosylases whose
activity regulates different pathways, including DNA damage repair, cell survival and …

Cocoa, rich in polyphenols, has been reported to provide many health benefits due to its
antioxidant properties. In this study, we investigated the effect of Cocoa polyphenols extract …

Aging is the subject of many studies, facilitating the discovery of many interventions.
Epigenetic influences numerous life processes by regulating gene expression and also …

Multiple myeloma (MM) is an incurable plasma cell malignancy, which is predominantly a
disease of older adults (the median age at diagnosis is 70 years). The slow progression from …

Parkinson's disease (PD) is the most common neurodegenerative disorder with motor
symptoms. The neuropathological alterations characterizing the brain of patients with PD …

Aging is a dynamic and progressive process mediated by reactive oxygen species (ROS),
and the antioxidant enzyme superoxide dismutase (SOD) can effectively scavenge ROS to …

Epigenetic mechanisms play a primary role in the cellular damage associated with brain
aging. Histone posttranslational modifications represent intrinsic molecular alterations …

Billions of years of co-evolution has made mitochondria central to the eukaryotic cell and
organism life playing the role of cellular power plants, as indeed they are involved in most, if …

The heat shock factor 1 (HSF1)-mediated stress response pathway and autophagy
processes play important roles in the maintenance of proteostasis. Autophagy processes are …