Eosinophils are bone marrow‐derived granulocytes and are found in low numbers in the
peripheral blood of healthy subjects. In type 2 inflammatory diseases, eosinopoiesis in the …

Abstract New leukotriene B4 (LTB4) antagonists have been synthesized that can be
considered as potential anti-inflammatory drugs. Structures containing the dioxygenated …

Background Succinate, although most famous for its role in the Krebs cycle, can be released
extracellularly as a signal of cellular distress, particularly in situations of metabolic stress …

Thiazole and piperazine are two important heterocyclic rings that play a prominent role in
nature and have a broad range of applications in agricultural and medicinal chemistry …

Atopy is an exaggerated IgE-mediated immune response to foreign antigens in which
metabolic abnormalities of the leukotrienes (LTs) pathway play a crucial role. Recent studies …

Asthma is a respiratory inflammatory disease, and nicotinamide adenine dinucleotide
phosphate oxidase 4 (NOX4) is involved in the progression of respiratory diseases …

At its introduction in the management of pediatric asthma, montelukast was regarded as a
potentially revolutionary drug due to its mechanism of action and easy clinical applicability …

Allergic disease is the 6 th leading cause of chronic illness in the US and accounts for
billions of dollars in healthcare annually. Mast cells are tissue resident innate immune cells …