Nicotinamide adenine dinucleotide in aging biology: potential applications and many unknowns
Recent research has unveiled an expansive role of NAD+ in cellular energy generation,
redox reactions, and as a substrate or cosubstrate in signaling pathways that regulate health …
redox reactions, and as a substrate or cosubstrate in signaling pathways that regulate health …
Vitamin A and retinoid signaling in the kidneys
K DiKun, LJ Gudas - Pharmacology & Therapeutics, 2023 - Elsevier
Vitamin A (VA, retinol) and its metabolites (commonly called retinoids) are required for the
proper development of the kidney during embryogenesis, but retinoids also play key roles in …
proper development of the kidney during embryogenesis, but retinoids also play key roles in …
Unified mouse and human kidney single-cell expression atlas reveal commonalities and differences in disease states
Background Mouse models have been widely used to understand kidney disease
pathomechanisms and play an important role in drug discovery. However, these models …
pathomechanisms and play an important role in drug discovery. However, these models …
Nicotinamide Riboside, a Promising Vitamin B3 Derivative for Healthy Aging and Longevity: Current Research and Perspectives
A Biţă, IR Scorei, MV Ciocîlteu, OE Nicolaescu… - Molecules, 2023 - mdpi.com
Many studies have suggested that the oxidized form of nicotinamide adenine dinucleotide
(NAD+) is involved in an extensive spectrum of human pathologies, including …
(NAD+) is involved in an extensive spectrum of human pathologies, including …
The complexity of nicotinamide adenine dinucleotide (NAD), hypoxic, and aryl hydrocarbon receptor cell signaling in chronic kidney disease
CS Curran, JB Kopp - Journal of Translational Medicine, 2023 - Springer
Early-stage detection of chronic kidney diseases (CKD) is important to treatment that may
slow and occasionally halt CKD progression. CKD of diverse etiologies share similar …
slow and occasionally halt CKD progression. CKD of diverse etiologies share similar …
Curcumin-loaded graphene oxide quantum dots enhance otoprotective effects via blocking cuproptosis
A Hu, JW Zhang, LY Yang, PP Qiao, D Lu… - … in Bioengineering and …, 2023 - frontiersin.org
Background: Cisplatin (CIS) is widely used to treat various cancers but can cause ototoxicity
and sensory hair cell loss in the inner ear. Copper induces an excessive production of …
and sensory hair cell loss in the inner ear. Copper induces an excessive production of …
Targeting mitochondrial metabolites and nucleic acids as an anti-inflammatory strategy
Y Min, LAJ O'Neill - Frontiers in Drug Discovery, 2023 - frontiersin.org
Mitochondrial metabolites and their derivatives have been the focus of recent efforts to
develop new anti-inflammatory therapeutics. The widely used therapeutic agents dimethyl …
develop new anti-inflammatory therapeutics. The widely used therapeutic agents dimethyl …
Hepatocyte nuclear factor 4α mediated quinolinate phosphoribosylltransferase (QPRT) expression in the kidney facilitates resilience against acute kidney injury
Nicotinamide adenine dinucleotide (NAD+) levels decline in experimental models of acute
kidney injury (AKI). Attenuated enzymatic conversion of tryptophan to NAD+ in tubular …
kidney injury (AKI). Attenuated enzymatic conversion of tryptophan to NAD+ in tubular …
CircRNA itchy E3 ubiquitin protein ligase improves mitochondrial dysfunction in sepsis-induced acute kidney injury by targeting microRNA-214-3p/ATP-binding …
W Ye, Q Miao, G Xu, K Jin, X Li, W Wu, L Yu, M Yan - Renal Failure, 2023 - Taylor & Francis
Abstract Background Circular RNAs (circRNAs) are promising biomarkers and therapeutic
targets for acute kidney injury (AKI). In this study, we investigated the mechanism by which …
targets for acute kidney injury (AKI). In this study, we investigated the mechanism by which …
HNF4α mediated QPRT expression in the kidney facilitates resilience against acute kidney injury
Nicotinamide adenine dinucleotide (NAD+) levels decline in experimental models of acute
kidney injury (AKI). Attenuated enzymatic conversion of tryptophan to NAD+ in tubular …
kidney injury (AKI). Attenuated enzymatic conversion of tryptophan to NAD+ in tubular …