First-phase insulin secretion: can its evaluation direct therapeutic approaches?

G Di Giuseppe, G Ciccarelli, L Soldovieri… - Trends in Endocrinology …, 2023 - cell.com
Our work is aimed at unraveling the role of the first-phase insulin secretion in the natural
history of type 2 diabetes mellitus (T2DM) and its interrelationship with insulin resistance …

Update on diabetic kidney disease (DKD): focus on non-albuminuric DKD and cardiovascular risk

S Scilletta, M Di Marco, N Miano, A Filippello… - Biomolecules, 2023 - mdpi.com
The classic description of diabetic kidney disease (DKD) involves progressive stages of
glomerular hyperfiltration, microalbuminuria, proteinuria, and a decline in the estimated …

Statin initiation and risk of incident kidney disease in patients with diabetes

S Zhou, L Su, R Xu, Y Li, R Chen, Y Cao, P Gao… - Cmaj, 2023 - Can Med Assoc
Background: The role of statin therapy in the development of kidney disease in patients with
type 2 diabetes mellitus (DM) remains uncertain. We aimed to determine the relationships …

Self-Management of Diabetes and Associated Factors among Patients Seeking Chronic Care in Tshwane, South Africa: A Facility-Based Study

J Zwane, P Modjadji, S Madiba, L Moropeng… - International Journal of …, 2023 - mdpi.com
The burden of diabetes continues to increase in South Africa and a significant number of
diabetes patients present at public primary healthcare facilities with uncontrolled glucose …

Positive feedback loop of miR-320 and CD36 regulates the hyperglycemic memory-induced diabetic diastolic cardiac dysfunction

J Zhan, K Jin, N Ding, Y Zhou, G Hu, S Yuan… - … Therapy-Nucleic Acids, 2023 - cell.com
Intensive glycemic control is insufficient for reducing the risk of heart failure among patients
with diabetes mellitus (DM). While the" hyperglycemic memory" phenomenon is well …

Empagliflozin is associated with lower risk of cardiovascular events and all‐cause mortality in routine care in East Asia: Results from the EMPRISE study

DJ Kim, WHH Sheu, WJ Chung, D Yabe… - Journal of Diabetes …, 2023 - Wiley Online Library
Abstract Aims/Introduction The EMPA‐REG OUTCOME® trial demonstrated benefits of
empagliflozin, a sodium‐glucose cotransporter‐2 inhibitor (SGLT2i), on cardiovascular …

A systematic review of cost-effectiveness studies of newer non-insulin antidiabetic drugs: Trends in decision-analytical models for modelling of type 2 diabetes mellitus

HVB Laursen, EP Jørgensen, P Vestergaard… - …, 2023 - Springer
Background We performed a systematic overview of the cost-effectiveness analyses (CEAs)
comparing Non-insulin antidiabetic drugs (NIADs) with other NIADs for the treatment of type …

Multimodal prehabilitation for major surgery in elderly patients to lower complications: Protocol of a randomised, prospective, multicentre, multidisciplinary trial …

CM Beilstein, G Krutkyte, T Vetsch, P Eser, M Wilhelm… - BMJ open, 2023 - bmjopen.bmj.com
Introduction The global volume of surgery is growing and the population ageing, and
economic pressure is rising. Major surgery is associated with relevant morbidity and …

[HTML][HTML] Exploring facilitators and barriers to patient-provider communication regarding diabetes self-management

BO Kirk, R Khan, D Davidov, U Sambamoorthi, R Misra - PEC innovation, 2023 - Elsevier
Objective Long-term type 2 diabetes management requires open communication between a
patient and their provider for self-care adherence. This study explored facilitators and …

Metformin-NSAIDs molecular salts: A path towards enhanced oral bioavailability and stability

FJ Acebedo-Martínez, A Domínguez-Martín… - Pharmaceutics, 2023 - mdpi.com
According to the World Health Organization, more than 422 million people worldwide have
diabetes. The most common oral treatment for type 2 diabetes is the drug metformin (MTF) …