Molecular mechanisms of environmental exposures and human disease
A substantial proportion of disease risk for common complex disorders is attributable to
environmental exposures and pollutants. An appreciation of how environmental pollutants …
environmental exposures and pollutants. An appreciation of how environmental pollutants …
Ageing as a software design flaw
JP de Magalhães - Genome Biology, 2023 - Springer
Ageing is inherent to all human beings, yet why we age remains a hotly contested topic.
Most mechanistic explanations of ageing posit that ageing is caused by the accumulation of …
Most mechanistic explanations of ageing posit that ageing is caused by the accumulation of …
Effect of long-term caloric restriction on DNA methylation measures of biological aging in healthy adults from the CALERIE trial
The geroscience hypothesis proposes that therapy to slow or reverse molecular changes
that occur with aging can delay or prevent multiple chronic diseases and extend healthy …
that occur with aging can delay or prevent multiple chronic diseases and extend healthy …
Biomarkers of aging for the identification and evaluation of longevity interventions
With the rapid expansion of aging biology research, the identification and evaluation of
longevity interventions in humans have become key goals of this field. Biomarkers of aging …
longevity interventions in humans have become key goals of this field. Biomarkers of aging …
Molecular mechanisms of vascular health: insights from vascular aging and calcification
Cardiovascular disease is the most common cause of death worldwide, especially beyond
the age of 65 years, with the vast majority of morbidity and mortality due to myocardial …
the age of 65 years, with the vast majority of morbidity and mortality due to myocardial …
Psychological and biological mechanisms linking trauma with cardiovascular disease risk
Cardiovascular disease (CVD) is the leading cause of death and disability worldwide, and
experiences of psychological trauma have been associated with subsequent CVD onset …
experiences of psychological trauma have been associated with subsequent CVD onset …
Racial and ethnic residential segregation and monocyte DNA methylation age acceleration
MT Hicken, J Dou, KN Kershaw, Y Liu, A Hajat… - JAMA network …, 2023 - jamanetwork.com
Importance Neighborhood segregation and poverty may be important drivers of health
inequities. Epigenomic factors, including DNA methylation clocks that may mark underlying …
inequities. Epigenomic factors, including DNA methylation clocks that may mark underlying …
DNA methylation age at birth and childhood: performance of epigenetic clocks and characteristics associated with epigenetic age acceleration in the Project Viva …
Background Epigenetic age acceleration (EAA) and epigenetic gestational age acceleration
(EGAA) are biomarkers of physiological development and may be affected by the perinatal …
(EGAA) are biomarkers of physiological development and may be affected by the perinatal …
[HTML][HTML] DNAmFitAge: biological age indicator incorporating physical fitness
Physical fitness is a well-known correlate of health and the aging process and DNA
methylation (DNAm) data can capture aging via epigenetic clocks. However, current …
methylation (DNAm) data can capture aging via epigenetic clocks. However, current …
Systemic inflammation and biological aging in the Health and Retirement Study
Chronic, low-level systemic inflammation associated with aging, or inflammaging, is a risk
factor for several chronic diseases and mortality. Using data from the Health and Retirement …
factor for several chronic diseases and mortality. Using data from the Health and Retirement …