Skeletal ring enlargement is gaining renewed interest in synthetic chemistry and has
recently focused on insertion of one or two atoms. Strategies for heterocyclic expansion …

Intermolecular cyclopropanation of mono-, di-, and trisubstituted olefins with α-bromo-β-
ketoesters and α-bromomalonates under organophotocatalysis is reported. The reaction …

The divergent synthesis of natural products is rapidly developing towards achieving the goal
of efficiency and economy in total synthesis. However, presently, the sustainable …

An efficient alkoxyl radical-triggered ring expansion/cross-coupling cascade was developed
under cheap metal catalysis. Through the metal-catalyzed radical relay strategy, a wide …

Radical initiators such as azo compounds and organic peroxides have been widely used to
facilitate numerous transformations of free radicals, which enable the efficient synthesis of …

Natural product chemistry is constantly challenged by newly discovered, complex
molecules. Elements of complexity arise from unprecedented frameworks, with a large …

The Dowd–Beckwith reaction, a ring-expansion of carbonyl compounds via alkoxy radicals,
is a powerful approach for synthesizing medium to large-sized carbocyclic scaffolds, which …

The asymmetric total synthesis of (−)-retigeranic acid A was described, which relies on a
crucial reductive skeletal rearrangement cascade for the controllable assembly of diverse …

A CuBr-mediated direct insertion of alkenes into unstrained ring 2-aryl-1, 3-indandiones is
reported, which provides a one-carbon ring expansion strategy for the synthesis of 1, 4 …

Herein, we report the synthesis of a series of colibactin warhead model compounds using
two newly developed metal‐free photocatalytic cyclopropanation reactions. These mild …