[HTML][HTML] AIM2 and psoriasis

Y Zhang, X Xu, H Cheng, F Zhou - Frontiers in Immunology, 2023 - frontiersin.org
Psoriasis is a chronic inflammatory skin disease occurring worldwide, with multiple systemic
complications, which seriously affect the quality of life and physical and mental health of …

Disentangling the complexity of psoriasis in the post-genome-wide association era

C Antonatos, K Grafanaki, S Georgiou, E Evangelou… - Genes & …, 2023 - nature.com
In recent years, genome-wide association studies (GWAS) have been instrumental in
unraveling the genetic architecture of complex diseases, including psoriasis. The application …

Single‐cell transcriptomics reveals prominent expression of IL‐14, IL‐18, and IL‐32 in psoriasis

B Frost, M Schmidt, B Klein… - European Journal of …, 2023 - Wiley Online Library
Rationale Psoriasis is a chronic inflammatory skin disease involving different cytokines and
chemokines. Objectives Here we use single‐cell transcriptomic analyses to identify relevant …

A Transcriptome-Wide Analysis of Psoriasis: Identifying the Potential Causal Genes and Drug Candidates

Y Jeong, J Song, Y Lee, E Choi, Y Won, B Kim… - International Journal of …, 2023 - mdpi.com
Psoriasis is a chronic inflammatory skin disease characterized by cutaneous eruptions and
pruritus. Because the genetic backgrounds of psoriasis are only partially revealed, an …

Immunosuppression causes dynamic changes in expression QTLs in psoriatic skin

Q Xiao, J Mears, A Nathan, K Ishigaki… - Nature …, 2023 - nature.com
Psoriasis is a chronic, systemic inflammatory condition primarily affecting skin. While the role
of the immune compartment (eg, T cells) is well established, the changes in the skin …

Considerations of the Genetic Background of Obesity among Patients with Psoriasis

A Czarnecka, D Purzycka-Bohdan, M Zabłotna… - Genes, 2023 - mdpi.com
Psoriasis comorbidities may emerge from pleiotropic mechanisms, including common
proinflammatory pathways, cellular mediators or genetic predisposition. Obesity is …

Genome-wide association analysis unveils candidate genes and loci associated with aplasia cutis congenita in pigs

F Zhou, S Wang, H Qin, H Zeng, J Ye, J Yang, G Cai… - BMC genomics, 2023 - Springer
Background Aplasia cutis congenita (ACC) is a rare genetic disorder characterized by the
localized or widespread absence of skin in humans and animals. Individuals with ACC may …

Patient-specific logical models replicate phenotype responses to psoriatic and anti-psoriatic stimuli.

E Tsirvouli, E Aker, M Kuiper - bioRxiv, 2023 - biorxiv.org
Psoriasis is a dermatologic disease that affects 2% of the world population. Psoriasis is
characterized by chronic inflammation and aberrant behavior of keratinocytes, which display …

IL-17A exacerbates psoriasis in a STAT3 overexpressing mouse model

X Xie, L Zhang, Y Lin, X Liu, N Wang, P Li - PeerJ, 2023 - peerj.com
Background Psoriasis is an autoimmune skin disease characterized by immunocyte
activation, excessive proliferation, and abnormal differentiation of keratinocytes. Signal …

Response of Psoriasis with Systemic Lupus Erythematosus to Secukinumab: A Case Report and Review of the Literature

B Dai, Y Bai, HD Yu, Q Huang… - Clinical, Cosmetic and …, 2023 - Taylor & Francis
Although psoriasis and systemic lupus erythematosus are both immune abnormalities, there
are few reports on Ps combined with SLE in China and abroad. We present a case of a 23 …