Cytokines are secreted signalling proteins that play essential roles in the initiation,
maintenance and resolution of immune responses. Although the unique ability of cytokines …

In the era of precision medicine, multivalent and multispecific therapeutics present a
promising approach for targeted disease intervention. These therapeutics are designed to …

Abstract The interleukin-4 (IL-4) cytokine plays a critical role in modulating immune
homeostasis. Although there is great interest in harnessing this cytokine as a therapeutic in …

The interleukin-6 (IL-6) family cytokines signal through gp130 receptor homodimerization or
heterodimerization with a second signaling receptor and play crucial roles in various cellular …

In CASP15, 87 predictors submitted around 11 000 models on 41 assembly targets. The
community demonstrated exceptional performance in overall fold and interface contact …

Many growth factors and cytokines signal by binding to the extracellular domains of their
receptors and driving association and transphosphorylation of the receptor intracellular …

Cytokines are soluble factors vital for mammalian physiology. Cytokines elicit highly
pleiotropic activities, characterized by their ability to induce a wide spectrum of functional …

The thrombopoietin receptor (TpoR) plays a central role in myeloproliferative neoplasms
(MPNs). Mutations in JAK2, calreticulin, or TpoR itself drive the constitutive activation of …

Pseudosymmetric hetero-oligomers with three or more unique subunits with overall
structural (but not sequence) symmetry play key roles in biology, and systematic approaches …

Discrete protein assemblies ranging from hundreds of kilodaltons to hundreds of
megadaltons in size are a ubiquitous feature of biological systems and perform highly …