In 1985 to 1986, the CARDIA (Coronary Artery Risk Development in Young Adults) study
enrolled 5115 Black or White participants, including 2788 women, aged 18 to 30 years. Over …

Mendelian randomization (MR) is the use of genetic variants to assess the existence of a
causal relationship between a risk factor and an outcome of interest. Here, we focus on two …

Spinobulbar muscular atrophy (SBMA) is caused by CAG expansions in the androgen
receptor gene. Androgen binding to polyQ-expanded androgen receptor triggers SBMA …

Aims/hypothesis Serum sex hormone-binding globulin (SHBG) has been proposed to act as
a hepatokine that contributes to the extrahepatic complications observed in non-alcoholic …

Neurodevelopmental disorders (NDDs) and congenital anomalies (CAs) are rare disorders
with complex etiology. In this study, we investigated the less understood genomic overlap of …

Introduction: Copy number variations (CNVs) play a critical role in the pathogenesis of
neurodevelopmental disorders (NDD) among children. In this study, we aim to identify …

The Framingham Heart Study (FHS) began in 1949 with the goal of defining the
epidemiology of hypertensive or arteriosclerotic heart disease in the population of …

BRCA1 and BRCA2 are the most mutated genes in breast cancer. We analyzed 48 breast
cancer subjects using two methods that differ in terms of number of genes investigated and …

Male infertility is significantly influenced by the plasma-protein sex hormone-binding
globulin (SHBG). Male infertility, erectile dysfunction, prostate cancer, and several other …

Background: Males are more likely than females to suffer from cardiovascular disease
(CVD). So, sex hormones may modify these variations and affect the lipid profile. We …