Next generation exon 51 skipping antisense oligonucleotides for Duchenne muscular dystrophy

J van Deutekom, C Beekman, S Bijl… - nucleic acid …, 2023 - liebertpub.com
In the last two decades, antisense oligonucleotides (AONs) that induce corrective exon
skipping have matured as promising therapies aimed at tackling the dystrophin deficiency …

Humanization of the mdx Mouse Phenotype for Duchenne Muscular Dystrophy Modeling: A Metabolic Perspective

G Donen, N Milad, P Bernatchez - Journal of Neuromuscular …, 2023 - content.iospress.com
Duchenne muscular dystrophy (DMD) is a severe form of muscular dystrophy (MD) that is
characterized by early muscle wasting and lethal cardiorespiratory failure. While the mdx …

Multiomic characterization of disease progression in mice lacking dystrophin

M Signorelli, R Tsonaka, A Aartsma-Rus, P Spitali - PLoS One, 2023 - journals.plos.org
Duchenne muscular dystrophy (DMD) is caused by genetic mutations leading to lack of
dystrophin in skeletal muscle. A better understanding of how objective biomarkers for DMD …

Spatial transcriptomics reveal markers of histopathological changes in Duchenne muscular dystrophy mouse models

LGM Heezen, T Abdelaal, M Van Putten… - Nature …, 2023 - nature.com
Duchenne muscular dystrophy is caused by mutations in the DMD gene, leading to lack of
dystrophin. Chronic muscle damage eventually leads to histological alterations in skeletal …

In vivo shear wave elasticity imaging for assessment of diaphragm function in muscular dystrophy

J Lee, NO Myrie, G Jeong, WM Han, YC Jang… - Acta Biomaterialia, 2023 - Elsevier
Duchenne muscular dystrophy (DMD) causes patients to suffer from ambulatory disability
and cardiorespiratory failure, the latter of which leads to premature death. Due to its role in …

[HTML][HTML] Cobalt-induced neuro-behavioural alterations are accompanied by profound Purkinje cell and gut-associated responses in rats

A Akinrinde, K Adigun, O Mustapha - … Analysis, Health and …, 2023 - ncbi.nlm.nih.gov
Metal ions including cobalt (Co) ions reportedly exhibit neurotoxic and antimicrobial
properties. We hypothesized that oral exposure to Co may have implications for gut …

[PDF][PDF] artsma-Rus,., & Spitali, P.(2023)

M Signorelli, R Tsonaka - … in mice lacking d strophin.,(3 … - scholarlypublications …
Duchenne muscular dystrophy (DMD) is caused by genetic mutations leading to lack of
dystrophin in skeletal muscle. A better understanding of how objective biomarkers for DMD …