The mechanism and therapy of aortic aneurysms

J Gao, H Cao, G Hu, Y Wu, Y Xu, H Cui, HS Lu… - Signal transduction and …, 2023 - nature.com
Aortic aneurysm is a chronic aortic disease affected by many factors. Although it is generally
asymptomatic, it poses a significant threat to human life due to a high risk of rupture …

Vascular smooth muscle cells in intimal hyperplasia, an update

S Déglise, C Bechelli, F Allagnat - Frontiers in physiology, 2023 - frontiersin.org
Arterial occlusive disease is the leading cause of death in Western countries. Core
contemporary therapies for this disease include angioplasties, stents, endarterectomies and …

ER stress mediates Angiotensin II-augmented innate immunity memory and facilitates distinct susceptibilities of thoracic from abdominal aorta to aneurysm …

Y Lu, Y Sun, F Saaoud, Y Shao, K Xu, X Jiang… - Frontiers in …, 2023 - frontiersin.org
To determine the roles of endoplasmic reticulum (ER) stress and trained immunity, we
performed transcriptome analyses on the thoracic aorta (TA) and abdominal aorta (AA) from …

Pulmonary artery smooth muscle cell phenotypic switching: a key event in the early stage of pulmonary artery hypertension

B Ma, Y Cao, J Qin, Z Chen, G Hu, Q Li - Drug Discovery Today, 2023 - Elsevier
Highlights•PAH is a progressive pulmonary vascular disease characterized by excessive
pulmonary vasoconstriction and pulmonary vascular remodeling.•Although currently drugs …

Nanofiber-based stretchable electrodes for oriented culture and mechanotransduction monitoring of smooth muscle cells

CX Bi, KQ Jin, J Yan, Y Qin, F Hong, WH Huang… - ACS …, 2023 - ACS Publications
Vascular smooth muscle cells (SMCs) are circumferentially oriented perpendicular to the
blood vessel and maintain the contractile phenotype in physiological conditions. They can …

Arterial remodeling: the role of mitochondrial metabolism in vascular smooth muscle cells

HL Qin, JH Bao, JJ Tang, DY Xu… - American Journal of …, 2023 - journals.physiology.org
Arterial remodeling is a common pathological basis of cardiovascular diseases such as
atherosclerosis, vascular restenosis, hypertension, pulmonary hypertension, aortic …

[HTML][HTML] Bioprinted vascular tissue: Assessing functions from cellular, tissue to organ levels

H Jiang, X Li, T Chen, Y Liu, Q Wang, Z Wang, J Jia - Materials Today Bio, 2023 - Elsevier
Abstract 3D bioprinting technology is widely used to fabricate various tissue structures.
However, the absence of vessels hampers the ability of bioprinted tissues to receive oxygen …

Recent advances in 3D printing sacrificial templates for fabricating engineered vasculature

S Li, H Li, X Shang, J He, Y Hu - MedComm–Biomaterials and …, 2023 - Wiley Online Library
Fabricating engineered vasculature within biological scaffolds is one of the most common
strategies to maintain high cell viability before implantation. Many studies have been …

Integrating oculomics with genomics reveals imaging biomarkers for preventive and personalized prediction of arterial aneurysms

Y Huang, C Li, D Shi, H Wang, X Shang, W Wang… - EPMA Journal, 2023 - Springer
Objective Arterial aneurysms are life-threatening but usually asymptomatic before requiring
hospitalization. Oculomics of retinal vascular features (RVFs) extracted from retinal fundus …

Aortic smooth muscle TRPV4 channels regulate vasoconstriction in high salt-induced hypertension

X Wen, Y Peng, Y Peng, Y Zhu, F Yu, L Geng… - Hypertension …, 2023 - nature.com
Recent studies have focused on the contribution of vascular endothelial transient receptor
potential vanilloid 4 (TRPV4) channels to hypertension. However, in hypertension, TRPV4 …