Nucleic acid sensing is involved in viral infections, immune response-related diseases, and
therapeutics. Based on the composition of nucleic acids, nucleic acid sensors are defined as …

In mammals, phospholipase D (PLD) enzymes involve 6 isoforms, of which only three have
established lipase activity to produce the signaling lipid phosphatidic acid (PA). This …

Lysosomal acid lipase (LAL) is the sole lysosomal enzyme responsible for the degradation
of cholesteryl esters and triacylglycerols at acidic pH. Impaired LAL activity leads to LAL …

Background In systemic lupus erythematosus (SLE), autoreactive B cells are thought to
develop by-passing immune checkpoints and contribute to its pathogenesis. Toll-like …

Abstract Phospholipase D4 (PLD4) is an endolysosomal exonuclease of ssRNA and ssDNA,
rather than a phospholipase as its name suggests. Human polymorphisms in the PLD4 gene …

Background The optimal diagnosis and treatment of tuberculosis (TB) are challenging due to
underdiagnosis and inadequate treatment monitoring. Lipid-related genes are crucial …

Endolysosomal exonucleases PLD3 and PLD4 (phospholipases D3 and D4) are associated
with autoinflammatory and autoimmune diseases. We report structures of these enzymes …

Background & Aims: Biliary atresia (BA) is an obstructive newborn jaundice disease that
leads to liver failure in the majority of affected infants. Viral infection is an important …

Abrogating synaptotoxicity in age-related neurodegenerative disorders is an extremely
promising area of research with significant neurotherapeutic implications in tauopathies …

Abstract Phospholipase D3 (PLD3) polymorphisms are linked to late-onset Alzheimer's
disease (LOAD). Being a lysosomal 5'-3'exonuclease, its neuronal substrates remained …