AlphaFold2 versus experimental structures: evaluation on G protein-coupled receptors
As important drug targets, G protein-coupled receptors (GPCRs) play pivotal roles in a wide
range of physiological processes. Extensive efforts of structural biology have been made on …
range of physiological processes. Extensive efforts of structural biology have been made on …
New insights into the structure and function of class B1 GPCRs
G protein–coupled receptors (GPCRs) are the largest family of cell surface receptors. Class
B1 GPCRs constitute a subfamily of 15 receptors that characteristically contain large …
B1 GPCRs constitute a subfamily of 15 receptors that characteristically contain large …
Structural basis of odorant recognition by a human odorant receptor
CB Billesbølle, CA de March, WJC van der Velden… - Nature, 2023 - nature.com
Our sense of smell enables us to navigate a vast space of chemically diverse odour
molecules. This task is accomplished by the combinatorial activation of approximately 400 …
molecules. This task is accomplished by the combinatorial activation of approximately 400 …
Structural insights into ligand recognition and activation of the medium-chain fatty acid-sensing receptor GPR84
GPR84 is an orphan class AG protein-coupled receptor (GPCR) that is predominantly
expressed in immune cells and plays important roles in inflammation, fibrosis, and …
expressed in immune cells and plays important roles in inflammation, fibrosis, and …
Profiling of basal and ligand-dependent GPCR activities by means of a polyvalent cell-based high-throughput platform
M Zeghal, G Laroche, JD Freitas, R Wang… - Nature …, 2023 - nature.com
Representing the most attractive and successful druggable receptors of the proteome,
GPCRs regulate a myriad of physiological and pathophysiological functions. Although over …
GPCRs regulate a myriad of physiological and pathophysiological functions. Although over …
Structural insights into the human niacin receptor HCA2-Gi signalling complex
The hydroxycarboxylic acid receptor 2 (HCA2) agonist niacin has been used as treatment for
dyslipidemia for several decades albeit with skin flushing as a common side-effect in treated …
dyslipidemia for several decades albeit with skin flushing as a common side-effect in treated …
Mechanism of activation and biased signaling in complement receptor C5aR1
The complement system plays an important role in the innate immune response to invading
pathogens. The complement fragment C5a is one of its important effector components and …
pathogens. The complement fragment C5a is one of its important effector components and …
Structural Insights into Molecular Recognition and Receptor Activation in Chemokine–Chemokine Receptor Complexes
L Urvas, E Kellenberger - Journal of Medicinal Chemistry, 2023 - ACS Publications
The chemokine system is a key player in the functioning of the immune system and a sought-
after target for drug candidates. The number of experimental structures of chemokines in …
after target for drug candidates. The number of experimental structures of chemokines in …
Mechanism of hormone and allosteric agonist mediated activation of follicle stimulating hormone receptor
Follicle stimulating hormone (FSH) is an essential glycoprotein hormone for human
reproduction, which functions are mediated by a G protein-coupled receptor, FSHR …
reproduction, which functions are mediated by a G protein-coupled receptor, FSHR …
Neurotensin receptor allosterism revealed in complex with a biased allosteric modulator
The NTSR1 neurotensin receptor (NTSR1) is a G protein-coupled receptor (GPCR) found in
the brain and peripheral tissues with neurotensin (NTS) being its endogenous peptide …
the brain and peripheral tissues with neurotensin (NTS) being its endogenous peptide …