The genetic basis of major depressive disorder

J Flint - Molecular psychiatry, 2023 - nature.com
The genetic dissection of major depressive disorder (MDD) ranks as one of the success
stories of psychiatric genetics, with genome-wide association studies (GWAS) identifying …

Clinical characteristics indexing genetic differences in bipolar disorder–a systematic review

HM van Loo, YA de Vries, J Taylor, L Todorovic… - Molecular …, 2023 - nature.com
Bipolar disorder is a heterogenous condition with a varied clinical presentation. While
progress has been made in identifying genetic variants associated with bipolar disorder …

The relationship between genotype-and phenotype-based estimates of genetic liability to human psychiatric disorders, in practice and in theory

MD Krebs, V Appadurai, KLG Hellberg, H Ohlsson… - medRxiv, 2023 - medrxiv.org
Genetics as a science has roots in studying phenotypes of relatives, but molecular
approaches facilitate direct measurements of genomic variation within individuals …

[HTML][HTML] Polygenic analyses show important differences between MDD symptoms collected using PHQ9 and CIDI-SF

L Huang, S Tang, J Rietkerk, V Appadurai, MD Krebs… - medRxiv, 2023 - ncbi.nlm.nih.gov
Abstract Symptoms of Major Depressive Disorder (MDD) are commonly assessed using self-
rating instruments like the Patient Health Questionnaire 9 (PHQ9, for current symptoms), and …