Dostarlimab for primary advanced or recurrent endometrial cancer

MR Mirza, DM Chase, BM Slomovitz… - … England Journal of …, 2023 - Mass Medical Soc
Background Dostarlimab is an immune-checkpoint inhibitor that targets the programmed cell
death 1 receptor. The combination of chemotherapy and immunotherapy may have …

Uterine neoplasms, version 1.2023, NCCN clinical practice guidelines in oncology

N Abu-Rustum, C Yashar, R Arend, E Barber… - Journal of the National …, 2023 - jnccn.org
Adenocarcinoma of the endometrium (also known as endometrial cancer, or more broadly
as uterine cancer or carcinoma of the uterine corpus) is the most common malignancy of the …

Current evidence-based systemic therapy for advanced and recurrent endometrial cancer

S Gordhandas, WA Zammarrelli, EV Rios-Doria… - Journal of the National …, 2023 - jnccn.org
Endometrial cancer (EC) is the most common gynecologic malignancy, with worldwide
increasing incidence and disease-associated mortality. Although most patients with EC are …

New insights for gynecological cancer therapies: from molecular mechanisms and clinical evidence to future directions

C Zhang, Y Sheng, X Sun, Y Wang - Cancer and Metastasis Reviews, 2023 - Springer
Advanced and recurrent gynecological cancers lack effective treatment and have poor
prognosis. Besides, there is urgent need for conservative treatment for fertility protection of …

Etiological relationship between lipid metabolism and endometrial carcinoma

W Li, Y Xu, X Zeng, J Tan, Y Wang, H Wu, M Li… - Lipids in Health and …, 2023 - Springer
Endometrial carcinoma (EC) has become one of the most common gynecological malignant
neoplasms in developed countries worldwide. Studies have shown that this may be closely …

[HTML][HTML] Combined PI3K inhibitor and eribulin enhances anti-tumor activity in preclinical models of paclitaxel-resistant, PIK3CA-mutated endometrial cancer

YG Jeong, NB Katuwal, MS Kang, M Ghosh, SD Hong… - Cancers, 2023 - mdpi.com
Simple Summary Paclitaxel-based chemotherapy is the standard front-line therapy for
advanced or metastatic endometrial cancer. However, paclitaxel resistance eternally …

The LIFR Inhibitor EC359 Effectively Targets Type II Endometrial Cancer by Blocking LIF/LIFR Oncogenic Signaling

N Spencer, AL Rodriguez Sanchez, R Gopalam… - International journal of …, 2023 - mdpi.com
Endometrial cancer (ECa) is the most common female gynecologic cancer. When comparing
the two histological subtypes of endometrial cancer, Type II tumors are biologically more …

The effect of progestin therapy in advanced and recurrent endometrial cancer: A systematic review and meta‐analysis

WJ Van Weelden, PB Birkendahl… - … Journal of Obstetrics …, 2023 - Wiley Online Library
Background Fifteen percent of patients with endometrial cancer (EC) have advanced stage
disease or develop a recurrence. Progestins have been applied as systemic treatment for …

[HTML][HTML] Association Between Intermediate End Points, Progression-free Survival, and Overall Survival in First-line Advanced or Recurrent Endometrial Cancer

J Garside, Q Shen, B Westermayer, M van de Ven… - Clinical Therapeutics, 2023 - Elsevier
Purpose Advanced/recurrent endometrial cancer is associated with poor long-term
outcomes. Clinical studies of novel regimens are ongoing, but given that data on overall …

[HTML][HTML] Healthcare Resource Utilization and Costs Among Commercially Insured Patients With Advanced or Recurrent Endometrial Cancer Initiating First-Line …

M Kobayashi, J Garside, J Nguyen - Journal of Health Economics …, 2023 - ncbi.nlm.nih.gov
Background: Endometrial cancer (EC) represents a substantial economic burden for patients
in the United States. Patients with advanced or recurrent EC have a much poorer prognosis …