Importance Approximately 20% to 30% of patients admitted to an intensive care unit have
sepsis. While fluid therapy typically begins in the emergency department, intravenous fluids …

Sepsis is a clinical syndrome encompassing physiologic and biological abnormalities
caused by a dysregulated host response to infection. Sepsis progression into septic shock is …

Importance Patients with septic shock undergo adrenergic stress, which affects cardiac,
immune, inflammatory, and metabolic pathways. β-Blockade may attenuate the adverse …

Artificial intelligence (AI) has great potential to improve the field of critical care and enhance
patient outcomes. This paper provides an overview of current and future applications of AI in …

Septic shock is a common condition associated with hypotension and organ dysfunction. It is
associated with high mortality rates of up to 60% despite the best recommended …

Sepsis causes significant morbidity and mortality worldwide. Resuscitation is a cornerstone
of management. This review covers five areas of evolving practice in the management of …

Abstract Study Objective Although fluid resuscitation is recommended by the Society of
Critical Care Medicine Surviving Sepsis Campaign Guidelines, risks of volume overload …

OBJECTIVES: To investigate the effects of immediate start of norepinephrine versus initial
fluid loading followed by norepinephrine on macro hemodynamics, regional splanchnic and …

Introduction Acute pancreatitis (AP) is characterised by an inflammatory response that in its
most severe form can cause a systemic dysregulated immune response and progression to …

There are several clinical practice guidelines concerning the use of fluid and vasoactive
drug therapies in critically ill adult patients, but the recommendations in these guidelines are …