The social origins of obesity within and across generations
We propose a model for obesity development that traces a considerable part of its origins to
the social domain (mainly different forms of prolonged social adversity), both within and …
the social domain (mainly different forms of prolonged social adversity), both within and …
[HTML][HTML] Parasites and childhood stunting–a mechanistic interplay with nutrition, anaemia, gut health, microbiota, and epigenetics
IL Gabain, AS Ramsteijn, JP Webster - Trends in Parasitology, 2023 - cell.com
Abstract Globally, stunting affects approximately 149.2 million children under 5 years of age.
The underlying aetiology and pathophysiological mechanisms leading to stunting remain …
The underlying aetiology and pathophysiological mechanisms leading to stunting remain …
[HTML][HTML] Novel epigenetic molecular therapies for imprinting disorders
SE Wang, Y Jiang - Molecular Psychiatry, 2023 - nature.com
Genomic imprinting disorders are caused by the disruption of genomic imprinting processes
leading to a deficit or increase of an active allele. Their unique molecular mechanisms …
leading to a deficit or increase of an active allele. Their unique molecular mechanisms …
DNA Methylation of Birthweight–Blood Pressure Genes and Changes of Blood Pressure in Response to Weight-Loss Diets in the POUNDS Lost Trial
Background: DNA methylation (DNAm) may play a critical role in bridging prenatal adverse
events and cardiometabolic disorders including hypertension in later life. Methods: We …
events and cardiometabolic disorders including hypertension in later life. Methods: We …
[HTML][HTML] Systemic interindividual epigenetic variation in humans is associated with transposable elements and under strong genetic control
CJ Gunasekara, H MacKay, CA Scott, S Li, E Laritsky… - Genome biology, 2023 - Springer
Background Genetic variants can modulate phenotypic outcomes via epigenetic
intermediates, for example at methylation quantitative trait loci (mQTL). We present the first …
intermediates, for example at methylation quantitative trait loci (mQTL). We present the first …
[HTML][HTML] Methodological approaches, challenges, and opportunities in the application of Mendelian randomisation to lifecourse epidemiology: A systematic literature …
Diseases diagnosed in adulthood may have antecedents throughout (including prenatal)
life. Gaining a better understanding of how exposures at different stages in the lifecourse …
life. Gaining a better understanding of how exposures at different stages in the lifecourse …
[HTML][HTML] Umbilical cord DNA methylation is associated with body mass index trajectories from birth to adolescence
Background DNA methylation (DNAm) in cord blood has been associated with various
prenatal factors and birth outcomes. This study sought to fill an important knowledge gap …
prenatal factors and birth outcomes. This study sought to fill an important knowledge gap …
[HTML][HTML] Toward Precision Weight-Loss Dietary Interventions: Findings from the POUNDS Lost Trial
The POUNDS Lost trial is a 2-year clinical trial testing the effects of dietary interventions on
weight loss. This study included 811 adults with overweight or obesity who were randomized …
weight loss. This study included 811 adults with overweight or obesity who were randomized …
Epigenetics applied to child and adolescent mental health: Progress, challenges and opportunities
Background Epigenetic processes are fast emerging as a promising molecular system in the
search for both biomarkers and mechanisms underlying human health and disease risk …
search for both biomarkers and mechanisms underlying human health and disease risk …
The role of DNA methylation in personalized medicine for immune-related diseases
Epigenetics functions as a bridge between host genetic & environmental factors, aiding in
human health and diseases. Many immune-related diseases, including infectious and …
human health and diseases. Many immune-related diseases, including infectious and …