Trans-corneal drug delivery strategies in the treatment of ocular diseases

L Li, F Jia, Y Wang, J Liu, Y Tian, X Sun, Y Lei… - Advanced Drug Delivery …, 2023 - Elsevier
The cornea is a remarkable tissue that possesses specialized structures designed to
safeguard the eye against foreign objects. However, its unique properties also make it …

Advancing biofilm management through nanoformulation strategies: a review of dosage forms and administration routes

O Simsekli, I Bilinmis, S Celik, G Arık… - Journal of Drug …, 2023 - Taylor & Francis
Biofilms are complex microbial communities formed by the attachment of bacteria or fungi to
surfaces encased in a self-produced polymeric matrix. These biofilms are highly resistant to …

Fabrication of betaxolol hydrochloride-loaded highly permeable ocular bilosomes (HPOBs) to combat glaucoma: In vitro, ex vivo & in vivo characterizations

MG Sakr, SA El-Zahaby, AM Al-Mahallawi… - Journal of Drug Delivery …, 2023 - Elsevier
Betaxolol hydrochloride is a water-soluble antiglaucoma drug suffering from poor ocular
bioavailability necessitating frequent dosing that impede patient adherence to treatment …

[HTML][HTML] Pharmaceutical approaches to Normal tension Glaucoma

ML Salvetat, F Pellegrini, L Spadea, C Salati… - Pharmaceuticals, 2023 - mdpi.com
Normal tension glaucoma (NTG) is defined as a subtype of primary open-angle glaucoma
(POAG) in which the intraocular pressure (IOP) values are constantly within the statistically …

In Vitro and Ex Vivo Models for Assessing Drug Permeation across the Cornea

I De Hoon, R Boukherroub, SC De Smedt… - Molecular …, 2023 - ACS Publications
Drug permeation across the cornea remains a major challenge due to its unique and
complex anatomy and physiology. Static barriers such as the different layers of the cornea …

[HTML][HTML] Development of Carvedilol Nanoformulation-Loaded Poloxamer-Based In Situ Gel for the Management of Glaucoma

BK Almutairy, ES Khafagy, AS Abu Lila - Gels, 2023 - mdpi.com
The objective of the current study was to fabricate a thermosensitive in situ gelling system for
the ocular delivery of carvedilol-loaded spanlastics (CRV-SPLs). In situ gel formulations …

[HTML][HTML] Recent overviews on the drug delivery aspects and applications of brinzolamide for the management of glaucoma

Y Sharma, K Chahar, L Mishra, L Kumari, A Singla… - Health Sciences …, 2023 - Elsevier
Brinzolamide (BRZ) is a highly selective carbonic anhydrase (CA) inhibitor which leads to
decreases intraocular pressure (IOP) by slowing down the production of aqueous humour. It …

[HTML][HTML] Formulation and Evaluation of Prednisolone Sodium Metazoate-Loaded Mucoadhesive Quatsomal Gel for Local Treatment of Recurrent Aphthous Ulcers …

A Kassem, H Refai, MA El-Nabarawi, MM Abdellatif - Pharmaceutics, 2023 - mdpi.com
This study aims to formulate a buccal mucoadhesive gel containing prednisolone sodium
metazoate-loaded quatsomes for efficient localized therapy of recurrent aphthous ulcers …