Functional bioengineered models of the central nervous system

N Rouleau, NJ Murugan, DL Kaplan - Nature Reviews Bioengineering, 2023 - nature.com
The functional complexity of the central nervous system (CNS) is unparalleled in living
organisms. Its nested cells, circuits and networks encode memories, move bodies and …

[HTML][HTML] Anisotropic 3d scaffolds for spinal cord guided repair: current concepts

JPM Sousa, E Stratakis, J Mano, PAAP Marques - Biomaterials Advances, 2023 - Elsevier
A spinal cord injury (SCI) can be caused by unforeseen events such as a fall, a vehicle
accident, a gunshot, or a malignant illness, which has a significant impact on the quality of …

Silk‐in‐Silk Nerve Guidance Conduits Enhance Regeneration in a Rat Sciatic Nerve Injury Model

L Semmler, A Naghilou, F Millesi, S Wolf… - Advanced …, 2023 - Wiley Online Library
Advanced nerve guidance conduits can provide an off‐the‐shelf alternative to autografts for
the rehabilitation of segmental peripheral nerve injuries. In this study, the excellent …

Biochemical mechanism involved in the enhancement of the Young's modulus of silk by the SpiCE protein

T Yoon, H Shin, W Park, Y Kim, S Na - Journal of the Mechanical Behavior …, 2023 - Elsevier
Silk fibers are known for their superior mechanical properties, with the strongest possessing
over seven times the toughness of kevlar. Recently, low molecular weight non-spidroin …

Generation of Haploid Spermatids on Silk Fibroin‐Alginate‐Laminin‐Based Porous 3D Scaffolds

Z Bashiri, A Moghaddaszadeh, R Falak… - Macromolecular …, 2023 - Wiley Online Library
In vitro production of sperm is a desirable idea for fertility preservation in azoospermic men
and prepubertal boys suffering from cancer. In this study, a biocompatible porous scaffold …

Halloysite nanoclay reinforced hydroxyapatite porous scaffold for hard tissue regeneration

U Yadav, V Verma - Journal of the Mechanical Behavior of Biomedical …, 2023 - Elsevier
Hydroxyapatite (HAP), a natural constituent of bone tissue is commonly used for the clinical
treatment of bone defects due to its similar structure with bone and excellent …

Novel Bioinspired Nerve Scaffold with High Synchrony between Biodegradation and Nerve Regeneration for Repair of Peripheral Nerve Injury

D Lan, B Wu, H Zhang, X Chen, Z Li, F Dai - Biomacromolecules, 2023 - ACS Publications
The morphological structure reconstruction and functional recovery of long-distance
peripheral nerve injury (PNI) are global medical challenges. Biodegradable nerve scaffolds …

Osteogenesis of Human iPSC‐Derived MSCs by PLLA/SF Nanofiber Scaffolds Loaded with Extracellular Matrix

J Zhang, L Che, Y Wu, L Zhou, L Liu… - Journal of Tissue …, 2023 - Wiley Online Library
Bone defects that arise from trauma, skeletal diseases, or tumor resections have become the
commonest and most thorny problems in orthopedic clinics. Recently, biocomposite …

Preparation and Properties of Antibacterial Silk Fibroin Scaffolds

P Pan, C Hu, A Liang, X Liu, M Fang, S Yang, Y Zhang… - Polymers, 2023 - mdpi.com
The development of a wound dressing with both antibacterial and healing-guiding functions
is a major concern in the treatment of open and infected wounds. In this study, poly …

A silk fibroin scaffold that accelerates both biodegradation and cell proliferation by incorporating sericin

W Zhang, X Sun, P Pan, X Liu, C Hu… - Journal of Bioactive …, 2023 - journals.sagepub.com
When 3D silk fibroin scaffolds are used for the regeneration of soft tissues with fast
regeneration rates, such as skin dermis, one concern is to accelerate the biodegradation of …