SARS-CoV-2-associated organs failure and inflammation: a focus on the role of cellular and viral microRNAs

R Rasizadeh, PS Aghbash, JS Nahand… - Virology journal, 2023 - Springer
SARS-CoV-2 has been responsible for the recent pandemic all over the world, which has
caused many complications. One of the hallmarks of SARS-CoV-2 infection is an induced …

Plasma miR-195-5p predicts the severity of Covid-19 in hospitalized patients

AI Moatar, AR Chis, M Romanescu, PD Ciordas… - Scientific Reports, 2023 - nature.com
Predicting the clinical course of Covid-19 is a challenging task, given the multi-systemic
character of the disease and the paucity of minimally invasive biomarkers of disease …

Multimodality cardiac imaging, cardiac symptoms, and clinical outcomes in patients who recovered from mild COVID-19

K Hanneman, C Houbois, T Kei, D Gustafson… - Radiology, 2023 - pubs.rsna.org
Background Many individuals have persistent cardiac symptoms after mild COVID-19
infection. However, studies assessing the relationship between symptoms and cardiac …

Vascular mechanisms of post-COVID-19 conditions: Rho-kinase is a novel target for therapy

RA Sykes, KB Neves, R Alves-Lopes… - European Heart …, 2023 - academic.oup.com
Background In post-coronavirus disease-19 (post-COVID-19) conditions (long COVID),
systemic vascular dysfunction is implicated, but the mechanisms are uncertain, and the …

A blood microRNA classifier for the prediction of ICU mortality in COVID-19 patients: a multicenter validation study

D de Gonzalo-Calvo, M Molinero, ID Benítez… - Respiratory …, 2023 - Springer
Background The identification of critically ill COVID-19 patients at risk of fatal outcomes
remains a challenge. Here, we first validated candidate microRNAs (miRNAs) as biomarkers …

Profibrotic COVID-19 subphenotype exhibits enhanced localized ER-dependent HSP47+ expression in cardiac myofibroblasts in situ

ER Jacobs, GR Ross, N Padilla, AY Pan, M Liegl… - Journal of Molecular and …, 2023 - Elsevier
We recently described a subgroup of autopsied COVID-19 subjects (∼ 40%), termed
'profibrotic phenotype,'who exhibited clusters of myofibroblasts (Mfbs), which were positive …

The chemorepellent, SLIT2, bolsters innate immunity against Staphylococcus aureus

VK Bhosle, C Sun, S Patel, TWW Ho, J Westman… - Elife, 2023 - elifesciences.org
Neutrophils are essential for host defense against Staphylococcus aureus (S. aureus). The
neuro-repellent, SLIT2, potently inhibits neutrophil chemotaxis, and might, therefore, be …

Human Genetic as Risk Factors for COVID-19 Progression

M Hosney, RR Sallam, MS Sayed - Egyptian Academic Journal of …, 2023 - journals.ekb.eg
Background: Thousands of people have already died as a result of the 2019 coronavirus
disease pandemic (COVID-19), which was brought on by the SARS-CoV-2 coronavirus …

Development of Vascularized Heart-on-a-Chip System for Studying Immune-Mediated Cardiovascular Dysfuncion

RXZ Lu - 2023 - search.proquest.com
The heart is one of the most vascularized organs in the body, with an equivalent number of
cardiomyocytes and endothelial cells present in the adult myocardium. Given their proximity …