Therapies modulating the immune system offer the prospect of treating a wide range of
conditions including infectious diseases, cancer and autoimmunity. Biomaterials can …

Secondary lymphoid organs, such as lymph nodes, harbor highly specialized and
compartmentalized niches. These niches are optimized to facilitate the encounter of naive …

The critical challenge for cancer vaccine‐induced T‐cell immunity is the sustained activation
of antigen cross‐presentation in antigen‐presenting cells (APCs) with innate immune …

Antibody responses are characterized by increasing affinity and diversity over time. Affinity
maturation occurs in germinal centers by a mechanism that involves repeated cycles of …

Multivalent viral epitopes induce rapid, robust and T cell-independent humoral immune
responses, but the biochemical basis for such potency remains incompletely understood …

To disseminate through the body, Zika virus (ZIKV) is thought to exploit the mobility of
myeloid cells, in particular monocytes and dendritic cells. However, the timing and …

B lymphocytes recognize bacterial or viral antigens via different classes of the B cell antigen
receptor (BCR). Protrusive structures termed microvilli cover lymphocyte surfaces, and are …

Macrophages facilitate critical functions in regulating pathogen clearance and immune
homeostasis in tissues. The remarkable functional diversity exhibited by macrophage …

Venezuelan equine encephalitis virus (VEEV) is an encephalitic alphavirus responsible for
epidemics of neurological disease across the Americas. Low-density lipoprotein receptor …

Cyanidin-3-O-glucoside (C3G), the most widely distributed anthocyanin (ACN) in edible
fruits, has been proposed for several bioactivities, including anti-inflammatory, neuro …