IntroductionCommon or non-syndromic obesity is a complex polygenic trait conditioned by
biallelic or single-base polymorphisms called SNPs (Single-Nucleotide Polymorphisms) that …

Diet modulates the genetic risk of obesity, but the modulation has been rarely studied using
genetic risk scores (GRSs) in children. Our objectives were to identify single nucleotide …

Whether the PGS developed using data from European ancestry is predictive of fracture risk
for minorities remains unclear. This study demonstrated that PGSs based on common BMD …

Background When polygenic risk score (PRS) is derived from summary statistics,
independence between discovery and test sets cannot be monitored. We compared two …

Several precedents support an association between single nucleotide genetic
polymorphisms (SNPs), the obese phenotype, and eating behavior in the infant-juvenile …

Genome wide association studies have identified numerous single nucleotide
polymorphisms (SNPs) associated with obesity, yet effect sizes of individual SNPs are small …

We assessed whether adding early life exposures to a model based on polygenic risk score
(PRS) improves prediction of obesity risk. We used a birth cohort with data at birth and BMI …

Evidence of a causal role for genes in human behavior underpins genetic essentialism, the
scientifically flawed and socially hazardous idea that heritable characteristics are immutable …

OBJECTIVE Environmental exposures may have greater predictive power for type 2
diabetes than polygenic scores (PGS). Studies examining environmental risk factors …

Introducción La obesidad común o no sindrómica es un rasgo poligénico complejo
condicionado por polimorfismos bialélicos o de un sola base denominados single …