Therapeutic strategies for COVID-19: progress and lessons learned

G Li, R Hilgenfeld, R Whitley, E De Clercq - Nature Reviews Drug …, 2023 - nature.com
Abstract The coronavirus disease 2019 (COVID-19) pandemic has stimulated tremendous
efforts to develop therapeutic strategies that target severe acute respiratory syndrome …

Possible pathogenesis and prevention of long COVID: SARS-CoV-2-induced mitochondrial disorder

TH Chen, CJ Chang, PH Hung - International journal of molecular …, 2023 - mdpi.com
Patients who have recovered from coronavirus disease 2019 (COVID-19) infection may
experience chronic fatigue when exercising, despite no obvious heart or lung abnormalities …

SARS-CoV-2 accessory proteins ORF7a and ORF3a use distinct mechanisms to down-regulate MHC-I surface expression

N Arshad, M Laurent-Rolle… - Proceedings of the …, 2023 - National Acad Sciences
Major histocompatibility complex class I (MHC-I) molecules, which are dimers of a
glycosylated polymorphic transmembrane heavy chain and the small-protein β2 …

A review on structural, non-structural, and accessory proteins of SARS-CoV-2: Highlighting drug target sites

MJ Islam, NN Islam, MS Alom, M Kabir, MA Halim - Immunobiology, 2023 - Elsevier
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), the causative agent of
COVID-19, is a highly transmittable and pathogenic human coronavirus that first emerged in …

Severe acute respiratory syndrome coronaviruses contributing to mitochondrial dysfunction: Implications for post-COVID complications

SP Kabekkodu, S Chakrabarty, P Jayaram, S Mallya… - Mitochondrion, 2023 - Elsevier
Mitochondria play a central role in oxidative phosphorylation (OXPHOS), bioenergetics
linked with ATP production, fatty acids biosynthesis, calcium signaling, cell cycle regulation …

SARS-CoV-2 accessory proteins involvement in inflammatory and profibrotic processes through IL11 signaling

BD López-Ayllón, A de Lucas-Rius… - Frontiers in …, 2023 - frontiersin.org
SARS-CoV-2, the cause of the COVID-19 pandemic, possesses eleven accessory proteins
encoded in its genome. Their roles during infection are still not completely understood. In …

The multiple roles of nsp6 in the molecular pathogenesis of SARS-CoV-2

C Bills, X Xie, PY Shi - Antiviral research, 2023 - Elsevier
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) continues to evolve and
adapt after its emergence in late 2019. As the causative agent of the coronavirus disease …

A neonatal mouse model characterizes transmissibility of SARS-CoV-2 variants and reveals a role for ORF8

BA Rodriguez-Rodriguez, GO Ciabattoni… - Nature …, 2023 - nature.com
Small animal models have been a challenge for the study of SARS-CoV-2 transmission, with
most investigators using golden hamsters or ferrets. Mice have the advantages of low cost …

SARS-CoV-2 and the DNA damage response

RJ Grand - Journal of General Virology, 2023 - microbiologyresearch.org
The recent coronavirus disease 2019 (COVID-19) pandemic was caused by severe acute
respiratory syndrome coronavirus 2 (SARS-CoV-2). COVID-19 is characterized by …

What do we know about the function of SARS-CoV-2 proteins?

S Justo Arevalo, A Castillo-Chávez… - Frontiers in …, 2023 - frontiersin.org
The COVID-19 pandemic has highlighted the importance in the understanding of the biology
of SARS-CoV-2. After more than two years since the first report of COVID-19, it remains …