[HTML][HTML] The benefits of hesperidin in central nervous system disorders, based on the neuroprotective effect

X Li, W Huang, R Tan, C Xu, X Chen, S Li, Y Liu… - Biomedicine & …, 2023 - Elsevier
Disorders of central nervous system (CNS) disorders are considered serious health issues.
The most common CNS diseases include neurodegenerative diseases, mental disorders …

Microglial activation in metal neurotoxicity: impact in neurodegenerative diseases

MI Martínez-Hernández… - BioMed Research …, 2023 - Wiley Online Library
Neurodegenerative processes encompass a large variety of diseases with different
pathological patterns and clinical features, such as Alzheimer's and Parkinson's diseases …

Beneficial effects of Chrysin on Cadmium‐induced nephrotoxicity in rats: Modulating the levels of Nrf2/HO‐1, RAGE/NLRP3, and Caspase-3/Bax/Bcl-2 signaling …

H Şimşek, N Akaras, C Gür, S Küçükler, FM Kandemir - Gene, 2023 - Elsevier
Cadmium (Cd) is a toxic heavy metal that targets the kidney directly in the body. Chrysin
(CHR) is a natural flavonoid with many properties such as antioxidant, anti-inflammatory and …

Mechanisms of cadmium neurotoxicity

MA Arruebarrena, CT Hawe, YM Lee… - International Journal of …, 2023 - mdpi.com
Cadmium is a heavy metal that increasingly contaminates food and drink products. Once
ingested, cadmium exerts toxic effects that pose a significant threat to human health. The …

Hesperidin plays beneficial roles in disorders associated with the central nervous system: A review

AV Atoki, PM Aja, TS Shinkafi, EN Ondari… - International Journal of …, 2023 - Taylor & Francis
Significant levels of flavonoids with antioxidant properties can be found in citrus species.
Flavonoids are a class of plant chemical known for a wide range of pharmacological …

Overview of caffeine effects on human health and emerging delivery strategies

SM Saraiva, TA Jacinto, AC Gonçalves, D Gaspar… - Pharmaceuticals, 2023 - mdpi.com
Caffeine is a naturally occurring alkaloid found in various plants. It acts as a stimulant,
antioxidant, anti-inflammatory, and even an aid in pain management, and is found in several …

[HTML][HTML] Cadmium-promoted thyroid hormones disruption mediates ROS, inflammation, Aβ and Tau proteins production, gliosis, spongiosis and neurodegeneration in …

E Sola, P Moyano, A Flores, JM García, J García… - Chemico-Biological …, 2023 - Elsevier
Cadmium (Cd) produces cognition decline following single and repeated treatment,
although the complete mechanisms are still unrevealed. Basal forebrain (BF) cholinergic …

Molybdenum and cadmium co-induce pyroptosis via inhibiting Nrf2-mediated antioxidant defense response in the brain of ducks

Z Hu, G Nie, J Luo, R Hu, G Li, G Hu… - Biological Trace Element …, 2023 - Springer
Excess molybdenum (Mo) and cadmium (Cd) are harmful to animals, but the neurotoxic
mechanism co-induced by Mo and Cd is unclear. To estimate the effects of Mo and Cd co …

Involvement of the heat shock response (HSR) regulatory pathway in cadmium-elicited cerebral damage

M Talukder, SS Bi, MW Lv, J Ge, C Zhang… - … Science and Pollution …, 2023 - Springer
The heat shock response (HSR) is a cellular protective mechanism that is characterized by
the induction of heat shock transcription factors (HSFs) and heat shock proteins (HSPs) in …

Caffeic acid, a polyphenolic micronutrient rescues mice brains against Aβ-induced neurodegeneration and memory impairment

A Khan, JS Park, MH Kang, HJ Lee, J Ali, M Tahir… - Antioxidants, 2023 - mdpi.com
Oxidative stress plays an important role in cognitive dysfunctions and is seen in
neurodegeneration and Alzheimer's disease (AD). It has been reported that the polyphenolic …