Role of Metabolic Adaptation of Streptococcus suis to Host Niches in Bacterial Fitness and Virulence

M Dresen, P Valentin-Weigand… - Pathogens, 2023 - mdpi.com
Streptococcus suis, both a common colonizer of the porcine upper respiratory tract and an
invasive pig pathogen, successfully adapts to different host environments encountered …

Dietary sugars silence the master regulator of carbohydrate utilization in human gut Bacteroides species

VH Pearce, EA Groisman, GE Townsend - Gut microbes, 2023 - Taylor & Francis
The mammalian gut microbiota is a critical human health determinant with therapeutic
potential for remediation of many diseases. The host diet is a key factor governing the gut …

StkP-and PhpP-mediated posttranslational modifications modulate the S. pneumoniae metabolism, polysaccharide capsule, and virulence

S Kant, Y Sun, V Pancholi - Infection and immunity, 2023 - Am Soc Microbiol
ABSTRACT Pneumococcal Ser/Thr kinase (StkP) and its cognate phosphatase (PhpP) play
a crucial role in bacterial cytokinesis. However, their individual and reciprocal metabolic and …

comCDE (Competence) Operon Is Regulated by CcpA in Streptococcus pneumoniae D39

Y Zhang, J Zhang, J Xiao, H Wang, R Yang… - Microbiology …, 2023 - Am Soc Microbiol
Natural transformation plays an important role in the formation of drug-resistant bacteria.
Exploring the regulatory mechanism of natural transformation can aid the discovery of new …

Identification and characterization of negative regulators of rgg1518 quorum sensing in streptococcus pneumoniae

D Hu, I Laczkovich, MJ Federle… - Journal of …, 2023 - Am Soc Microbiol
Streptococcus pneumoniae is an agent of otitis media, septicemia, and meningitis and
remains the leading cause of community-acquired pneumonia regardless of vaccine use. Of …

[HTML][HTML] Glucose levels affect MgaSpn regulation on the virulence and adaptability of Streptococcus pneumoniae

W Suo, X Guo, X Zhang, S Xiao, S Wang, Y Yin… - Microbial …, 2023 - Elsevier
Streptococcus pneumoniae can regulate virulence gene expression by sensing
environmental changes, which is key to its pathogenicity. The global transcription regulator …

CRISPRi-TnSeq: A genome-wide high-throughput tool for bacterial essential-nonessential genetic interaction mapping

B Jana, X Liu, J Dénéréaz, H Park, D Leshchiner, B Liu… - bioRxiv, 2023 - biorxiv.org
Genetic interaction networks can help identify functional connections between genes and
pathways, which can be leveraged to establish (new) gene function, drug targets, and fill …

DegU-mediated suppression of carbohydrate uptake in Listeria monocytogenes increases adaptation to oxidative stress

M Chen, G Ren, X Zhang, L Yang, Q Ding… - Applied and …, 2023 - Am Soc Microbiol
The foodborne bacterial pathogen Listeria monocytogenes exhibits remarkable survival
capabilities under challenging conditions, severely threatening food safety and human …

Group B Streptococcus Cas9 variants provide insight into programmable gene repression and CRISPR-Cas transcriptional effects

KP Gopalakrishna, GH Hillebrand, VH Bhavana… - Communications …, 2023 - nature.com
Abstract Group B Streptococcus (GBS; S. agalactiae) causes chorioamnionitis, neonatal
sepsis, and can also cause disease in healthy or immunocompromised adults. GBS …

Studies of Streptococcus anginosus Virulence in Dictyostelium discoideum and Galleria mellonella Models

J Budziaszek, M Pilarczyk-Zurek, E Dobosz… - Infection and …, 2023 - Am Soc Microbiol
For many years, Streptococcus anginosus has been considered a commensal colonizing the
oral cavity, as well as the gastrointestinal and genitourinary tracts. However, recent …